Mob1a MGI Mouse Gene Detail - MGI:2442631

Symbol

Mob1a
Name

MOB kinase activator 1A
Synonyms

4022402H07Rik, MGC:6884, Mobk1b, Mobkl1b

Feature Type

protein coding gene
IDs

MGI:2442631
NCBI Gene: 232157
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:83303016-83320758 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

1 experiment

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442631	protein coding gene	Chr6:83302998-83320758 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030929	protein coding gene	Chr6:84331294-84349276 (+)
A/J	MGP_AJ_G0030898	protein coding gene	Chr6:81120344-81138098 (+)
AKR/J	MGP_AKRJ_G0030826	protein coding gene	Chr6:83474878-83492490 (+)
BALB/cJ	MGP_BALBcJ_G0030908	protein coding gene	Chr6:81143436-81163171 (+)
C3H/HeJ	MGP_C3HHeJ_G0030802	protein coding gene	Chr6:100906559-100926031 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031368	protein coding gene	Chr6:86640970-86659186 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028554	protein coding gene	Chr6:79472489-79490195 (+)
CAST/EiJ	MGP_CASTEiJ_G0030017	protein coding gene	Chr6:83485575-83504943 (+)
CBA/J	MGP_CBAJ_G0030595	protein coding gene	Chr6:90057032-90074784 (+)
DBA/2J	MGP_DBA2J_G0030748	protein coding gene	Chr6:80438381-80456529 (+)
FVB/NJ	MGP_FVBNJ_G0030701	protein coding gene	Chr6:79643339-79662678 (+)
LP/J	MGP_LPJ_G0030827	protein coding gene	Chr6:84338923-84356568 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030737	protein coding gene	Chr6:94356835-94375657 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031392	protein coding gene	Chr6:83274766-83294371 (+)
PWK/PhJ	MGP_PWKPhJ_G0029732	protein coding gene	Chr6:79338696-79356311 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029560	protein coding gene	Chr6:82123238-82141617 (+)
WSB/EiJ	MGP_WSBEiJ_G0030098	protein coding gene	Chr6:83713508-83732213 (+)

Human Ortholog

MOB1A, MOB kinase activator 1A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MOB1A, MOB kinase activator 1A
Synonyms

C2orf6, MABKL1B, MATS1, MOB1, Mob4B, MOBK1B, MOBKL1B
Links

HGNC:16015

NCBI Gene ID: 55233

neXtProt AC: NX_Q9H8S9

UniProt: Q9H8S9
Chr Location

2p13.1; chr2:74152528-74178898 (-) GRCh38

MGI Vertebrate Homology

Mob1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MOB1A
Gene Tree

Mob1a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
51 phenotypes from multigenic genotypes
6 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Gene trapped

2
Spontaneous

1
Targeted

5
Genomic Mutations

2 involving Mob1a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit no abnormal phenotype.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

10
cDNA Data

277
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mob1a

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All Sequences

72
RefSeq

16
UniProt

3
CCDS

CCDS39533.1

Ensembl

ENSMUSG00000043131 (Evidence)
NCBI Gene

232157

			Length	Strain/Species	Flank
genomic	232157	NCBI Gene Model \| MGI Sequence Detail	17743	C57BL/6J	± kb
transcript	NM_001418175	RefSeq \| MGI Sequence Detail	4817	C57BL/6
polypeptide	Q921Y0	UniProt \| EBI \| MGI Sequence Detail	216	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010505 MOB kinase activator 1A

(term hierarchy)
InterPro Domains

IPR005301 MOB kinase activator family

IPR036703 MOB kinase activator superfamily

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All nucleic 277

cDNA 277

Microarray probesets 7

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 22
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:332523 Soyama H, et al., Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2123134119

TSS for Mob1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57346	Chr6:83303011-83303046 (+)	13 bp
Tssr57347	Chr6:83303053-83303067 (+)	44 bp
Tssr57348	Chr6:83304715-83304742 (+)	1,713 bp
Tssr57349	Chr6:83318561-83318576 (+)	15,553 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23