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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Kcnt1
potassium channel, subfamily T, member 1
MGI:1924627
39 phenotypes from 9 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Kcnt1em1(IMPC)Mbp/Kcnt1em1(IMPC)Mbp
C57BL/6N-Kcnt1em1(IMPC)Mbp/MbpMmucd
abnormal behavior J:211773
abnormal eye morphology J:211773
abnormal kidney morphology J:211773
abnormal spleen morphology J:211773
anophthalmia J:211773
decreased anxiety-related response J:211773
decreased exploration in new environment J:211773
decreased locomotor activity J:211773
decreased thigmotaxis J:211773
small kidney J:211773
small spleen J:211773
Kcnt1em1Nju/Kcnt1em1Nju
involves: C57BL/6J
abnormal nervous system electrophysiology J:333464
normal behavior/neurological phenotype J:333464
decreased thigmotaxis J:333464
impaired ability to fire action potentials J:333464
nervous system phenotype J:333464
Kcnt1em1Pqt/Kcnt1+
C57BL/6J-Kcnt1em1Pqt
normal behavior/neurological phenotype J:333512
Kcnt1em1Pqt/Kcnt1em1Pqt
C57BL/6J-Kcnt1em1Pqt
abnormal nest building behavior J:333512
decreased body size J:333512
decreased fear-related response J:333512
hyperactivity J:333512
increased anxiety-related response J:333512
premature death J:333512
preweaning lethality, incomplete penetrance J:333512
seizures J:333512
tonic-clonic seizures J:333512
Kcnt1em8Frk/Kcnt1em8Frk
C57BL/6NJ-Kcnt1em8Frk
abnormal CNS synaptic transmission J:300699
abnormal GABAergic neuron physiology J:300699
abnormal glutaminergic neuron morphology J:300699
abnormal nervous system morphology J:300699
abnormal nest building behavior J:300699
normal behavior/neurological phenotype J:300699
hyperactivity J:300699
impaired contextual conditioning behavior J:300699
impaired cued conditioning behavior J:300699
normal nervous system phenotype J:300699
seizures J:300699
tonic seizures J:300699
tonic-clonic seizures J:300699
Kcnt1em8Frk/Kcnt1em8Frk
involves: 129P2/OlaHsd * C57BL/6NJ * FVB
seizures J:300699
Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc
Tg(Scn10a-cre)1Rkun/0
involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2
abnormal mechanical nociception J:218978
Kcnt1tm1.1Clin/Kcnt1tm1.1Clin
B6.Cg-Kcnt1tm1.1Clin
no abnormal phenotype detected J:101977
Kcnt1tm1.2Acsc/Kcnt1tm1.2Acsc
B6N.Cg-Kcnt1tm1.2Acsc
abnormal mechanical nociception J:218978
abnormal sensory neuron physiology J:218978
impaired ability to fire action potentials J:218978
Kcnt1tm1.2Clin/Kcnt1+
B6.Cg-Kcnt1tm1.2Clin
increased pruritus J:228059
Kcnt1tm1.2Clin/Kcnt1tm1.2Clin
B6.Cg-Kcnt1tm1.2Clin
decreased channel response intensity J:228059
increased pruritus J:228059
Kcnt1tm1Dgen/Kcnt1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6J
abnormal action potential J:333464
abnormal nervous system electrophysiology J:333464
normal behavior/neurological phenotype J:333464
increased thigmotaxis J:333464
normal nervous system phenotype J:333464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory