Kcnt1^tm1.2Acsc
Targeted Allele Detail

Summary

• Symbol: Kcnt1^tm1.2Acsc
• Name: potassium channel, subfamily T, member 1; targeted mutation 1.2, Achim Schmidtko
• MGI ID: MGI:5708322
• Synonyms: Slack L1
• Gene: Kcnt1 Location: Chr2:25753807-25808285 bp, + strand Genetic Position: Chr2, 18.27 cM
• Alliance: Kcnt1^tm1.2Acsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218978
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed selection cassette was inserted upstream of exon 11 and a loxP site was inserted downstream of exon 11 via homologous recombination. Cre-mediated recombination removed the neo cassette and exon 11. (J:218978)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnt1 Mutation: 66 strains or lines available

References

• Original: J:218978 Lu R, et al., Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci. 2015 Jan 21;35(3):1125-35
• All: 6 reference(s)