Kcnt1^tm1.2Clin
Targeted Allele Detail

Summary

• Symbol: Kcnt1^tm1.2Clin
• Name: potassium channel, subfamily T, member 1; targeted mutation 1.2, Christopher J Lingle
• MGI ID: MGI:5908121
• Gene: Kcnt1 Location: Chr2:25753807-25808285 bp, + strand Genetic Position: Chr2, 18.27 cM
• Alliance: Kcnt1^tm1.2Clin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 11 and a second loxP site, followed by an FRT-flanked neomycin resistance (neo) cassette which includes a third loxP site, downstream of exon 11. Recombinase-mediated recombination removed the FRT-flanked neo cassette and exon 11. (J:228059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnt1 Mutation: 70 strains or lines available

References

• Original: J:228059 Martinez-Espinosa PL, et al., Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. 2015;4:e10013
• All: 3 reference(s)