Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation
(0 available);
any
Kcnt1 mutation
(66 available)
|
|
|
integument
|
• chloroquine, histamine or compound 48?80 elicit a robust enhancement of scratching behavior in the first 5 min after injection
|
nervous system
|
• absence of Na+-dependent leak current in dissociated dorsal root ganglions neurons
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation
(0 available);
any
Kcnt1 mutation
(66 available)
|
|
|
integument
|
• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation
(0 available);
any
Kcnt1 mutation
(66 available)
Kcnt2tm1.2Clin mutation
(0 available);
any
Kcnt2 mutation
(111 available)
|
|
|
behavior/neurological
|
• enhanced aversion to moderate doses of capsaicin
|
|
• briefer latency in a hot plate test
|
integument
|
• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection
|
nervous system
|
• in isolectin B4+ neurons increase in action potential firing and a decrease in threshold is seen
|
|
• absence of Na+-dependent leak current in dissociated small diameter dorsal root ganglions neurons
|