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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnt1tm1.2Clin
targeted mutation 1.2, Christopher J Lingle
MGI:5908121
Summary 3 genotypes


Genotype
MGI:5908187
hm1
Allelic
Composition		 Kcnt1tm1.2Clin/Kcnt1tm1.2Clin
Genetic
Background		 B6.Cg-Kcnt1tm1.2Clin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation (0 available); any Kcnt1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased pruritus ( J:228059 )
• chloroquine, histamine or compound 48?80 elicit a robust enhancement of scratching behavior in the first 5 min after injection

nervous system
decreased channel response intensity ( J:228059 )
• absence of Na+-dependent leak current in dissociated dorsal root ganglions neurons




Genotype
MGI:5908188
ht2
Allelic
Composition		 Kcnt1tm1.2Clin/Kcnt1+
Genetic
Background		 B6.Cg-Kcnt1tm1.2Clin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation (0 available); any Kcnt1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased pruritus ( J:228059 )
• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection




Genotype
MGI:5908190
cx3
Allelic
Composition		 Kcnt1tm1.2Clin/Kcnt1tm1.2Clin
Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic
Background		 B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.2Clin mutation (0 available); any Kcnt1 mutation (70 available)
Kcnt2tm1.2Clin mutation (0 available); any Kcnt2 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemical nociceptive threshold ( J:228059 )
• enhanced aversion to moderate doses of capsaicin
decreased thermal nociceptive threshold ( J:228059 )
• briefer latency in a hot plate test

integument
increased pruritus ( J:228059 )
• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection

nervous system
abnormal action potential ( J:228059 )
• in isolectin B4+ neurons increase in action potential firing and a decrease in threshold is seen
decreased channel response intensity ( J:228059 )
• absence of Na+-dependent leak current in dissociated small diameter dorsal root ganglions neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory