Mfsd2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
MGI:1923824

47 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mfsd2a^{tm1b(KOMP)Wtsi}/Mfsd2a⁺ C57BL/6N-Mfsd2a^{tm1b(KOMP)Wtsi}/Ucd	abnormal epididymis morphology	J:211773
	abnormal testis morphology	J:211773
	enlarged epididymis	J:211773
	enlarged testis	J:211773
Mfsd2a^{tm1b(KOMP)Wtsi}/Mfsd2a^{tm1b(KOMP)Wtsi} C57BL/6N-Mfsd2a^{tm1b(KOMP)Wtsi}/MbpMmucd	abnormal embryo size	J:211773
Mfsd2a^{tm1b(KOMP)Wtsi}/Mfsd2a^{tm1b(KOMP)Wtsi} C57BL/6N-Mfsd2a^{tm1b(KOMP)Wtsi}/Ucd	preweaning lethality, incomplete penetrance	J:211773
Mfsd2a^{tm1c(KOMP)Wtsi}/Mfsd2a^{tm1c(KOMP)Wtsi} involves: C57BL/6J * C57BL/6N	no abnormal phenotype detected	J:234197
Mfsd2a^{tm1c(KOMP)Wtsi}/Mfsd2a^{tm1c(KOMP)Wtsi} Tg(Tek-cre)1Ywa/0 involves: C57BL/6J * C57BL/6N	normal homeostasis/metabolism phenotype	J:234197
	microphthalmia	J:234197
Mfsd2a^tm1Dls/Mfsd2a^tm1Dls B6.Cg-Mfsd2a^tm1Dls	abnormal eye physiology	J:234197
	abnormal lipid homeostasis	J:234197
	abnormal liver morphology	J:194781
	abnormal microglial cell activation	J:234197
	abnormal nervous system physiology	J:234197
	abnormal retina outer nuclear layer morphology	J:234197
	abnormal retina pigment epithelium morphology	J:234197
	abnormal retina rod cell outer segment morphology	J:234197
	ataxia	J:194781
	decreased body length	J:194781
	decreased body weight	J:194781, J:234197
	decreased circulating triglyceride level	J:194781
	decreased lean body mass	J:194781
	decreased susceptibility to diet-induced obesity	J:194781
	decreased susceptibility to hepatic steatosis	J:194781
	decreased total body fat amount	J:194781
	decreased triglyceride level	J:194781
	decreased unsaturated fatty acids level	J:234197
	decreased vertical activity	J:194781
	decreased white fat cell size	J:194781
	disorganized photoreceptor outer segment	J:234197
	disorganized retina outer nuclear layer	J:234197
	normal homeostasis/metabolism phenotype	J:194781
	hyperactivity	J:194781
	increased energy expenditure	J:194781
	increased fatty acid oxidation	J:194781
	increased respiratory quotient	J:194781
	increased unsaturated fatty acids level	J:234197
	microphthalmia	J:234197
	normal nervous system phenotype	J:234197
	postnatal lethality, incomplete penetrance	J:194781
	retina degeneration	J:234197
	retina gliosis	J:234197
	retina outer nuclear layer degeneration	J:234197
	short photoreceptor outer segment	J:234197
	normal vision/eye phenotype	J:234197
Mfsd2a^tm1Lex/Mfsd2a^tm1Lex B6;129S5-Mfsd2a^tm1Lex/Mmucd	abnormal vascular endothelial cell physiology	J:210589
	abnormal vesicle-mediated transport	J:210589
	normal cardiovascular system phenotype	J:210589
	impaired blood-brain barrier function	J:210589

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23