71 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Becn1tm1.1Bflu/Becn1tm1.1Bflu Tg(Cd4-cre)1Cwi/0 involves: 129S1/Sv * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:203090
	decreased CD4-positive, alpha-beta T cell number	J:203090
	decreased CD8-positive, alpha-beta T cell number	J:203090
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:203090
	decreased T cell proliferation	J:203090
	increased T cell apoptosis	J:203090
Becn1tm1.1Ebr/Becn1+ Not Specified	abnormal ovary morphology	J:180916
Becn1tm1b(KOMP)Wtsi/Becn1+ C57BL/6N-Becn1tm1b(KOMP)Wtsi/Ieg	decreased circulating HDL cholesterol level	J:211773
	decreased lean body mass	J:211773
	increased circulating bilirubin level	J:211773
	increased leukocyte cell number	J:211773
	increased startle reflex	J:211773
	increased total body fat amount	J:211773
Becn1tm1b(KOMP)Wtsi/Becn1tm1b(KOMP)Wtsi C57BL/6N-Becn1tm1b(KOMP)Wtsi/Ieg	preweaning lethality, complete penetrance	J:211773
Becn1tm1Blev/Becn1+ involves: 129X1/SvJ * C57BL/6J	abnormal immune system morphology	J:86953
	abnormal mammary gland duct morphology	J:86953
	decreased tumor-free survival time	J:86953
	impaired autophagy	J:86953
	increased follicular lymphoma incidence	J:86953
	increased hepatocellular carcinoma incidence	J:86953
	increased histiocytic sarcoma incidence	J:86953
	increased lung adenocarcinoma incidence	J:86953
	increased lung adenoma incidence	J:86953
	increased lung carcinoma incidence	J:86953
	increased lymphoma incidence	J:86953
	increased malignant tumor incidence	J:86953
	increased mammary gland tumor incidence	J:86953
	increased plasmacytoma incidence	J:86953
	increased spleen germinal center number	J:86953
	increased spleen germinal center size	J:86953
	increased tumor incidence	J:86953
Becn1tm1Blev/Becn1tm1Blev involves: 129X1/SvJ	decreased myocardial infarct size	J:186597
	increased myocardial infarct size	J:186597
Becn1tm1Blev/Becn1tm1Blev involves: 129X1/SvJ * C57BL/6J	prenatal lethality, complete penetrance	J:86953
Becn1tm1Ebr/Becn1+ Tg(EIIa-cre)C5379Lmgd/? involves: FVB/N	abnormal brain development	J:180916
	abnormal heart development	J:180916
	embryonic lethality during organogenesis, incomplete penetrance	J:180916
Becn1tm1Ebr/Becn1+ Tg(MMTV-cre)1Mam/? involves: FVB	abnormal brain development	J:180916
	abnormal heart development	J:180916
	abnormal primordial ovarian follicle morphology	J:180916
	decreased primordial ovarian follicle number	J:180916
	embryonic lethality during organogenesis, incomplete penetrance	J:180916
	perinatal lethality	J:180916
	small ovary	J:180916
Becn1tm1Ebr/Becn1tm1Ebr Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd	abnormal circulating chemokine level	J:235399
	abnormal kidney morphology	J:235399
	abnormal macrophage physiology	J:235399
	abnormal renal glomerulus morphology	J:235399
	abnormal spleen morphology	J:235399
	decreased body weight	J:235399
	decreased circulating interleukin-10 level	J:235399
	glomerulonephritis	J:235399
	increased anti-double stranded DNA antibody level	J:235399
	increased anti-nuclear antigen antibody level	J:235399
	increased autoantibody level	J:235399
	increased blood urea nitrogen level	J:235399
	increased circulating creatinine level	J:235399
	increased circulating interleukin-1 beta level	J:235399
	increased circulating interleukin-6 level	J:235399
	increased circulating interleukin-12b level	J:235399
	increased IgG level	J:235399
	increased lymphocyte cell number	J:235399
	increased monocyte cell number	J:235399
	increased neutrophil cell number	J:235399
	increased susceptibility to systemic lupus erythematosus	J:235399
	increased urine protein level	J:235399
Becn1tm1Htz/Becn1+ involves: 129P2/OlaHsd * C57BL/6	increased B cell derived lymphoma incidence	J:86982
	increased hepatocellular carcinoma incidence	J:86982
	increased lung adenocarcinoma incidence	J:86982
	increased tumor incidence	J:86982
Becn1tm1Htz/Becn1tm1Htz involves: 129P2/OlaHsd	abnormal amnion morphology	J:86982
	absent amniotic folds	J:86982
	decreased embryo size	J:86982
	embryonic growth arrest	J:86982
	embryonic lethality between implantation and somite formation, complete penetrance	J:86982
	impaired autophagy	J:86982
	increased embryonic tissue cell apoptosis	J:86982
Becn1tm2.1Blev/Becn1tm2.1Blev B6.129-Becn1tm2.1Blev	no abnormal phenotype detected	J:244104