Becn1^tm2.1Blev
Targeted Allele Detail

Summary

• Symbol: Becn1^tm2.1Blev
• Name: beclin 1, autophagy related; targeted mutation 2.1, Beth Levine
• MGI ID: MGI:6156896
• Synonyms: Becn1^F121A, Becn1^FA, Becn1^tm1.1Hec
• Gene: Becn1 Location: Chr11:101179084-101193112 bp, - strand Genetic Position: Chr11, 64.58 cM, cytoband D
• Alliance: Becn1^tm2.1Blev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244104
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted in intron 7 and an F121A mutation was created in exon 6 via homologous recombination. Cre-meditated recombination removed the neo cassette. The mutation in exon 6 disrupts binding to BCL2 resulting in constitutively high autophagy. (J:244104)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Becn1 Mutation: 35 strains or lines available

References

• Original: J:244104 Rocchi A, et al., A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017 Aug;13(8):e1006962
• All: 14 reference(s)