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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
MGI:1353450
27 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Aldh1a1tm1.1(cre/ERT2)Cai/\Aldh1a1+
\Slc6a3tm1c(KOMP)Wtsi/\Slc6a3tm1c(KOMP)Wtsi
involves: C57BL/6N * SJL 		abnormal motor coordination/balance J:280705
normal behavior/neurological phenotype J:280705
\Aldh1a1tm1.1Ngb/\Aldh1a1tm1.1Ngb
\Aldh1a3tm1.1Pcn/\Aldh1a3tm1.1Pcn
involves: 129/Sv * C57BL/6 * SJL 		abnormal conjunctival sac morphology J:102847
abnormal cornea stroma development J:102847
abnormal eyelid development J:102847
abnormal nose morphology J:102847
absent Harderian gland J:102847
absent iris stroma J:102847
absent sclera J:102847
decreased periocular mesenchyme apoptosis J:102847
decreased ventral retina size J:102847
neonatal lethality, complete penetrance J:102847
persistent hyperplastic primary vitreous J:102847
respiratory distress J:102847
ventral rotation of lens J:102847
\Aldh1a1tm1Gdu/\Aldh1a1tm1Gdu
\Aldh1a2tm1.1Mbp/\Aldh1a2tm1.1Mbp
\Gt(ROSA)26Sortm1(cre/ERT2)Tyj/\Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal spermatogenesis J:324715
azoospermia J:324715
male infertility J:324715
\Aldh1a1tm1Gdu/\Aldh1a1tm1Gdu
\Aldh1a2tm1.1Mbp/\Aldh1a2tm1.2Mbp
\Plekha5Tg(AMH-cre)1Flor/\Plekha5+
involves: 129 * C57BL/6 * SJL 		abnormal spermatogenesis J:324715
azoospermia J:324715
decreased Sertoli cell number J:324715
male infertility J:324715
\Aldh1a1tm1Gdu/\Aldh1a1tm1Gdu
\Aldh1a2tm1.1Mbp/\Aldh1a2tm1.2Mbp
\Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6 * FVB/NJ 		normal reproductive system phenotype J:324715
\Aldh1a1tm1Gdu/\Aldh1a1tm1Gdu
\Aldh1a2tm1Gdu/\Aldh1a2tm1Gdu
\Aldh1a3tm1Gdu/\Aldh1a3tm1Gdu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal optic cup morphology J:108515
\Aldh1a1tm1Gdu/\Aldh1a1tm1Gdu
\Aldh1a3tm1Gdu/\Aldh1a3tm1Gdu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal periocular mesenchyme morphology J:108515
abnormal posterior eye segment morphology J:108515
abnormal vitreous body morphology J:108515
decreased periocular mesenchyme apoptosis J:108515
increased cornea stroma thickness J:108515
increased total retina thickness J:108515
persistent hyperplastic primary vitreous J:108515
thick eyelids J:108515
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory