About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr2f2
nuclear receptor subfamily 2, group F, member 2
MGI:1352452
83 phenotypes from 5 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd 		abnormal maternal decidual layer morphology J:120852
abnormal myometrium morphology J:120852
abnormal placenta development J:120852
abnormal placental labyrinth vasculature morphology J:120852
abnormal uterine environment J:120852
absent placental labyrinth J:120852
decreased spongiotrophoblast cell number J:120852
edema J:120852
embryonic lethality, incomplete penetrance J:120852
hemorrhage J:120852
impaired embryo implantation J:120852
increased miscarriage rate J:120852
increased trophoblast giant cell number J:120852
reduced female fertility J:120852
short uterine horn J:120852
vaginal hemorrhage J:120852
Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal cardiovascular system physiology J:227012
abnormal cell physiology J:227012
abnormal mitochondrial inner membrane morphology J:227012
abnormal mitochondrial physiology J:227012
abnormal mitochondrial shape J:227012
abnormal oxidative phosphorylation J:227012
abnormal respiratory electron transport chain J:227012
decreased cardiac muscle contractility J:227012
decreased fatty acid oxidation J:227012
decreased oxygen consumption J:227012
dilated cardiomyopathy J:227012
enlarged heart J:227012
premature death J:227012
Nkx3-2tm1(cre)Tsa/Nkx3-2+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6 		abnormal digestive system development J:98520
abnormal enteric neuron morphology J:98520
abnormal forestomach-glandular stomach junction morphology J:98520
abnormal gastric parietal cell morphology J:98520
abnormal stomach epithelium morphology J:98520
abnormal stomach glandular epithelium morphology J:98520
abnormal stomach morphology J:98520
abnormal stomach pyloric region morphology J:98520
abnormal stomach smooth muscle circular layer morphology J:98520
small forestomach J:98520
small stomach J:98520
Nr2f2tm1Tsa/Nr2f2+
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR) 		decreased body size J:54469
hemorrhage J:54469
postnatal lethality, incomplete penetrance J:54469
Nr2f2tm1Tsa/Nr2f2+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal ovary morphology J:100400
abnormal uterine horn morphology J:100400
absent estrous cycle J:100400
absent estrus J:100400
decreased circulating progesterone level J:100400
decreased litter size J:100400
delayed vaginal opening J:100400
postnatal growth retardation J:100400
prolonged diestrus J:100400
prolonged metestrus J:100400
reduced female fertility J:100400
Nr2f2tm1Tsa/Nr2f2tm1Tsa
either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR) 		abnormal anterior cardinal vein morphology J:54469
abnormal heart tube morphology J:54469
abnormal posterior cardinal vein morphology J:54469
abnormal vein morphology J:54469
absent trabeculae carneae J:54469
decreased angiogenesis J:54469
normal embryo phenotype J:120852
embryonic lethality during organogenesis, complete penetrance J:54469
hemorrhage J:54469
incomplete somite formation J:54469
Nr2f2tm1Vco/Nr2f2+
Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA 		abnormal glucose homeostasis J:98195
abnormal lipid level J:98195
decreased circulating glucose level J:98195
decreased fatty acids level J:98195
decreased insulin secretion J:98195
impaired glucose tolerance J:98195
increased circulating insulin level J:98195
increased circulating triglyceride level J:98195
increased insulin secretion J:98195
insulin resistance J:98195
Nr2f2tm1Vco/Nr2f2tm1Vco
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		perinatal lethality, incomplete penetrance J:98195
Nr2f2tm1Vco/Nr2f2tm1Vco
Tg(Ins2-cre)25Mgn/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA 		prenatal lethality, complete penetrance J:98195
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd 		reduced female fertility J:120852
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:98247
abnormal vein morphology J:98247
embryonic lethality, complete penetrance J:98247
hemorrhage J:98247
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		female infertility J:162256
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(rx3-icre)1Mjam/0
involves: 129S7/SvEvBrd 		normal vision/eye phenotype J:157924
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL 		decreased lymphatic vessel endothelial cell number J:158959
Tg(Tek-Nr2f2)1Tsa/0
Not Specified 		abnormal embryo turning J:98247
abnormal vitelline vascular remodeling J:98247
arteriovenous malformation J:98247
embryonic growth retardation J:98247
embryonic lethality during organogenesis, complete penetrance J:98247
pericardial effusion J:98247
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory