Nr2f2^tm1Vco
Targeted Allele Detail

Summary

• Symbol: Nr2f2^tm1Vco
• Name: nuclear receptor subfamily 2, group F, member 2; targeted mutation 1, Mireille Vasseur-Cognet
• MGI ID: MGI:3578106
• Synonyms: COUP-TFII fl
• Gene: Nr2f2 Location: Chr7:70001692-70016483 bp, - strand Genetic Position: Chr7, 38.66 cM
• Alliance: Nr2f2^tm1Vco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98195
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 1 with loxP sites. Transient transfection of cre recombinase excised a floxed neo inserted into intron 1. (J:98195)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2f2 Mutation: 27 strains or lines available

References

• Original: J:98195 Bardoux P, et al., Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout. Diabetes. 2005 May;54(5):1357-1363
• All: 2 reference(s)