Analysis Tools
mortality/aging
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• survivors were apparently normal and fertile with expected life spans
• about 50% of homozygotes die between E18.5 and birth
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Allele Symbol Allele Name Allele ID |
Nr2f2tm1Vco targeted mutation 1, Mireille Vasseur-Cognet MGI:3578106 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• survivors were apparently normal and fertile with expected life spans
• about 50% of homozygotes die between E18.5 and birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• death occurs before E18.5, possibly due to extrapancreatic cre expression
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• virtually no insulin release in response to glucose challenge
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• slightly higher levels of release under basal conditions
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• slightly lower plasma glucose levels when fasted
• glucose levels normal when fed
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• higher plasma insulin levels whether fed or fasted
• plasma insulin/glucagons ratio increased about 2X
• 20 minutes after glucose challenge, insulin levels are lower than in controls
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• glucose intolerant when tested on animals fasted overnight
• very high initial glucose levels after glucose challenge
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• levels remain elevated when fed
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• decreased free fatty acid levels when fasted
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• virtually no insulin release in response to glucose challenge
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• slightly higher levels of release under basal conditions
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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