Phenotypes associated with this allele

• Allele Symbol: Nr2f2^tm1Vco
• Allele Name: targeted mutation 1, Mireille Vasseur-Cognet
• Allele ID: MGI:3578106
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr2f2^tm1Vco/Nr2f2^tm1Vco	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3578327
cn2	Nr2f2^tm1Vco/Nr2f2^tm1Vco Tg(Ins2-cre)25Mgn/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA	MGI:3578328
cn3	Nr2f2^tm1Vco/Nr2f2^+ Tg(Ins2-cre)25Mgn/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA	MGI:3578329

Genotype
MGI:3578327

hm1

• Allelic Composition: Nr2f2^tm1Vco/Nr2f2^tm1Vco
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:98195 )

• survivors were apparently normal and fertile with expected life spans

• about 50% of homozygotes die between E18.5 and birth

Genotype
MGI:3578328

cn2

• Allelic Composition: Nr2f2^tm1Vco/Nr2f2^tm1Vco; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA

mortality/aging

prenatal lethality, complete penetrance ( J:98195 )

• death occurs before E18.5, possibly due to extrapancreatic cre expression

Genotype
MGI:3578329

cn3

• Allelic Composition: Nr2f2^tm1Vco/Nr2f2⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA

homeostasis/metabolism

abnormal glucose homeostasis ( J:98195 )

decreased insulin secretion ( J:98195 )

• virtually no insulin release in response to glucose challenge

increased insulin secretion ( J:98195 )

• slightly higher levels of release under basal conditions

decreased circulating glucose level ( J:98195 )

• slightly lower plasma glucose levels when fasted

• glucose levels normal when fed

increased circulating insulin level ( J:98195 )

• higher plasma insulin levels whether fed or fasted

• plasma insulin/glucagons ratio increased about 2X

• 20 minutes after glucose challenge, insulin levels are lower than in controls

impaired glucose tolerance ( J:98195 )

• glucose intolerant when tested on animals fasted overnight

• very high initial glucose levels after glucose challenge

insulin resistance ( J:98195 )

abnormal lipid level ( J:98195 )

increased circulating triglyceride level ( J:98195 )

• levels remain elevated when fed

decreased fatty acids level ( J:98195 )

• decreased free fatty acid levels when fasted

endocrine/exocrine glands

decreased insulin secretion ( J:98195 )

• virtually no insulin release in response to glucose challenge

increased insulin secretion ( J:98195 )

• slightly higher levels of release under basal conditions