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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Casp8tm1Clie/Casp8tm1Clie
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * FVB/N 		abnormal bile duct morphology J:160521
abnormal liver morphology J:160521
bile duct proliferation J:160521
focal hepatic necrosis J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating bilirubin level J:160521
normal mortality/aging J:160521
postnatal growth retardation J:160521
Commd10Tg(Vav1-icre)A2Kio/0
Map3k7tm1.1Arte/Map3k7tm1.1Arte
involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca 		decreased interleukin-6 secretion J:332172
decreased interleukin-10 secretion J:332172
decreased interleukin-12b secretion J:332172
decreased macrophage cell number J:332172
decreased tumor necrosis factor secretion J:332172
enlarged axillary lymph nodes J:332172
enlarged inguinal lymph nodes J:332172
enlarged spleen J:332172
increased B cell number J:332172
increased lymphocyte cell number J:332172
increased neutrophil cell number J:332172
increased splenocyte number J:332172
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * FVB/N 		normal homeostasis/metabolism phenotype J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased hepatocyte apoptosis J:160521
increased hepatocyte proliferation J:160521
normal liver/biliary system phenotype J:160521
normal mortality/aging J:160521
Map3k7tm1Aki/Map3k7tm1Aki
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 		normal cardiovascular system phenotype J:191285
normal cellular phenotype J:191285
dilated vasculature J:191285
embryonic lethality during organogenesis, complete penetrance J:191285
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory