Ikbkgtm1.1Chtr
Targeted Allele Detail
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Symbol: |
Ikbkgtm1.1Chtr |
Name: |
inhibitor of kappaB kinase gamma; targeted mutation 1.1, Christian Trautwein |
MGI ID: |
MGI:4355682 |
Synonyms: |
NemoFl |
Gene: |
Ikbkg Location: ChrX:73436896-73497460 bp, + strand Genetic Position: ChrX, 38.0 cM
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Alliance: |
Ikbkgtm1.1Chtr page
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Ikbkgtm1.1Chtr/Y Tg(Alb1-cre)7Gsc/0 mice are protected from anti-Fas mAb stimulated development of hepatitis
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:151485
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removed the neo cassette leaving exon 2 floxed.
(J:151485)
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Generation of the Ikbkgtm1.1Chtr allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ikbkg Mutation: |
15 strains or lines available
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Original: |
J:151485 Beraza N, et al., Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. J Exp Med. 2009 Aug 3;206(8):1727-37 |
All: |
16 reference(s) |
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