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Ikbkg Gene Detail
Summary
  • Symbol
    Ikbkg
  • Name
    inhibitor of kappaB kinase gamma
  • Synonyms
    1110037D23Rik, IKK[g], NEMO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338074
    NCBI Gene: 16151
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73436896-73497460 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 38.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338074
 protein coding gene ChrX:73436883-73498013 (+)
129S1/SvImJ ENSMUSG00200040230
 protein coding gene ChrX:55531697-55557797 (+)
A/J ENSMUSG00195034516
 protein coding gene ChrX:59207717-59233815 (+)
AKR/J ENSMUSG00220043456
 protein coding gene ChrX:54510037-54536135 (+)
BALB/cJ ENSMUSG00180048922
 protein coding gene ChrX:55788468-55814562 (+)
C3H/HeJ ENSMUSG00175033215
 protein coding gene ChrX:59372054-59398152 (+)
C57BL/6NJ ENSMUSG00215040589
 protein coding gene ChrX:55872656-55898750 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033187
 protein coding gene ChrX:69444220-69510507 (+)
CAST/EiJ ENSTCUG00005039732
 protein coding gene ChrX:57284516-57308673 (+)
CBA/J ENSMUSG00210035827
 protein coding gene ChrX:56052756-56078854 (+)
DBA/2J ENSMUSG00185030496
 protein coding gene ChrX:68474497-68500595 (+)
FVB/NJ ENSMUSG00205020891
 protein coding gene ChrX:55353800-55379898 (+)
JF1/MsJ ENSUMUG00000039010
 protein coding gene ChrX:89209336-89233494 (+)
LP/J ENSMUSG00230034010
 protein coding gene ChrX:75053811-75079909 (+)
NOD/ShiLtJ ENSMUSG00190042861
 protein coding gene ChrX:55292734-55318832 (+)
NZO/HlLtJ ENSMUSG00225046556
 protein coding gene ChrX:80258214-80284312 (+)
PWK/PhJ ENSLUMG00010044854
 protein coding gene ChrX:55030507-55054671 (+)
SPRET/EiJ ENSMSPG00010034866
 protein coding gene ChrX:58114391-58141088 (+)
WSB/EiJ ENSIUOG00005046186
 protein coding gene ChrX:56120003-56146103 (+)



Homology
more
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKBKG, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  • Synonyms
    AMCBX1, EDAID1, FIP-3, FIP3, Fip3p, IKKAP1, IKKG, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, SAIDX, ZC2HC9
  • Links
    NCBI Gene ID: 8517
    UniProt: Q9Y6K9

  • Chr Location
    Xq28; chrX:154541179-154565047 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ikbkg mouse models; 6 with human IKBKG associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    95 phenotypes from 8 alleles in 13 genetic backgrounds
    36 phenotypes from multigenic genotypes
    6 images
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for targeted null mutations exhibit embryonic lethality by embryonic day 13.5 from apoptotic liver damage. Heterozygous females show patchy skin lesions with granulocyte infiltration, growth retardation, and shortened lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    24
  • cDNA Data
    108
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004221 Ensembl Gene Model | MGI Sequence Detail 60565 C57BL/6J ±  kb
    transcript ENSMUST00000004330 Ensembl | MGI Sequence Detail 6918 Not Applicable  
    polypeptide ENSMUSP00000004330 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1
      Antibodies 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1923574, MGI:2147920, MGI:2147925, MGI:2148001
    References
    more
    • Summaries
      All 277
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 34
      Phenotypes 96
    • Earliest
      J:21378 Tebo JM, et al., Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Immunol. 1994 Nov 15;153(10):4713-20
    • Latest
      J:386289 Liang X, et al., Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK. Cell Rep. 2025 Oct 28;44(10):116404
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory