Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and signaling adaptor activity. Involved in several processes, including anoikis; canonical NF-kappaB signal transduction; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within B cell homeostasis and positive regulation of canonical NF-kappaB signal transduction. Located in cytoplasm. Is expressed in early conceptus; genitourinary system; and musculature. Used to study Bloch-Sulzberger syndrome and steatotic liver disease. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma).