Casp8^tm1Clie
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1Clie
• Name: caspase 8; targeted mutation 1, Christian Liedtke
• MGI ID: MGI:4461018
• Synonyms: Casp8^Fl, Caspase-8^loxP
• Gene: Casp8 Location: Chr1:58834533-58886662 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1Clie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160521
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked by loxP sites. A FRT flanked Neo cassette was inserted upstream of exon 3 and removed via Flp-mediated recombination. (J:160521, J:218665)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 42 strains or lines available

References

• Original: J:160521 Bettermann K, et al., TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell. 2010 May 18;17(5):481-96
• All: 4 reference(s)