Pak1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pak1
p21 (RAC1) activated kinase 1
MGI:1339975

22 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pak1^em1Yuwa/Pak1⁺ FVB/N-Pak1^em1Yuwa	decreased papilloma incidence	J:323200
Pak1^em1Yuwa/Pak1^em1Yuwa FVB/N-Pak1^em1Yuwa	decreased papilloma incidence	J:323200
Pak1^em2Yuwa/Pak1⁺ FVB/N-Pak1^em2Yuwa	normal neoplasm	J:323200
Pak1^em2Yuwa/Pak1^em2Yuwa FVB/N-Pak1^em2Yuwa	normal neoplasm	J:323200
Pak1^tm1.1Xwg/Pak1^tm1.1Xwg B6.129-Pak1^tm1.1Xwg	no abnormal phenotype detected	J:193804
Pak1^tm1.1Xwg/Pak1^tm1.1Xwg Myl2^tm1(cre)Krc/Myl2⁺ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	cardiac fibrosis	J:193804
	cardiac hypertrophy	J:193804
	congestive heart failure	J:193804
	decreased cardiac muscle contractility	J:193804
	increased cardiomyocyte apoptosis	J:193804
	increased heart weight	J:193804
	increased myocardial fiber size	J:193804
	increased response of heart to induced stress	J:193804
	pulmonary edema	J:193804
Pak1^{tm1b(EUCOMM)Hmgu}/Pak1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pak1^{tm1b(EUCOMM)Hmgu}/H	decreased bone mineral content	J:211773
	decreased prepulse inhibition	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating triglyceride level	J:211773
	increased total body fat amount	J:211773
Pak1^tm1Cher/Pak1^tm1Cher B6.129S2-Pak1^tm1Cher	abnormal mast cell physiology	J:142439
Pak1^tm1Cher/Pak1^tm1Cher B6.129S2-Pak1^tm1Cher	decreased mast cell degranulation	J:145444
Pak1^tm1Cher/Pak1^tm1Cher involves: 129S2/SvPas	normal hematopoietic system phenotype	J:195865
Pak1^tm1Zpj/Pak1^tm1Zpj involves: 129S1/Sv * 129X1/SvJ	normal nervous system phenotype	J:225714
Pak1^tm1Zpj/Pak1^tm1Zpj involves: 129S1/Sv * 129X1/SvJ	reduced long-term potentiation	J:225714

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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