Pak1^tm1Zpj
Targeted Allele Detail

Summary

• Symbol: Pak1^tm1Zpj
• Name: p21 (RAC1) activated kinase 1; targeted mutation 1, Zhengping Jia
• MGI ID: MGI:5694233
• Gene: Pak1 Location: Chr7:97437748-97561588 bp, + strand Genetic Position: Chr7, 53.57 cM
• Alliance: Pak1^tm1Zpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225714
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a part of the ATG in exon 1 and adjacent upstream intronic sequence. Western blot analysis confirmed the absence of protein expression in the brain. (J:225714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pak1 Mutation: 36 strains or lines available

References

• Original: J:225714 Asrar S, et al., Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1). Neuropharmacology. 2009 Jan;56(1):73-80
• All: 6 reference(s)