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Pak1 Gene Detail
Summary
  • Symbol
    Pak1
  • Name
    p21 (RAC1) activated kinase 1
  • Synonyms
    PAK-1, Paka
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339975
    NCBI Gene: 18479
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97437748-97561588 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2884 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339975
 protein coding gene Chr7:97437748-97561588 (+)
129S1/SvImJ ENSMUSG00200047648
 protein coding gene Chr7:84262321-84385822 (+)
A/J ENSMUSG00195035562
 protein coding gene Chr7:88767280-88890786 (+)
AKR/J ENSMUSG00220046078
 protein coding gene Chr7:82184555-82308070 (+)
BALB/cJ ENSMUSG00180034864
 protein coding gene Chr7:85440666-85564172 (+)
C3H/HeJ ENSMUSG00175022188
 protein coding gene Chr7:86095725-86221013 (+)
C57BL/6NJ ENSMUSG00215031959
 protein coding gene Chr7:85278779-85404764 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030009
 protein coding gene Chr7:100456861-100582489 (+)
CAST/EiJ ENSTCUG00005029910
 protein coding gene Chr7:88667378-88793600 (+)
CBA/J ENSMUSG00210025086
 protein coding gene Chr7:85943682-86068951 (+)
DBA/2J ENSMUSG00185030641
 protein coding gene Chr7:90270387-90395675 (+)
FVB/NJ ENSMUSG00205021122
 protein coding gene Chr7:85941912-86062516 (+)
JF1/MsJ ENSUMUG00000030843
 protein coding gene Chr7:95170267-95294379 (+)
LP/J ENSMUSG00230040361
 protein coding gene Chr7:96379362-96502843 (+)
NOD/ShiLtJ ENSMUSG00190021103
 protein coding gene Chr7:86213929-86337420 (+)
NZO/HlLtJ ENSMUSG00225050720
 protein coding gene Chr7:94565770-94689263 (+)
PWK/PhJ ENSLUMG00010045936
 protein coding gene Chr7:84385425-84509876 (+)
SPRET/EiJ ENSMSPG00010009821
 protein coding gene Chr7:85609606-85737872 (+)
WSB/EiJ ENSIUOG00005009528
 protein coding gene Chr7:86549005-86672715 (+)



Homology
more
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAK1, p21 (RAC1) activated kinase 1
  • Synonyms
    alpha-PAK, IDDMSSD, p65-PAK, PAKalpha
  • Links
    NCBI Gene ID: 5058
    UniProt: Q13153

  • Chr Location
    11q13.5-q14.1; chr11:77321548-77530009 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PAK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display defects in allergen-induced mast cell migration and degranulation. Mice homozygous for a different knock-out allele exhibit reduced long term potentiation. A C>T mutation at position 6 in the 3' UTR affects the use of the proximal poly(A) signal and reduces susceptibility to developing papillomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    143
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1075
  • Tissues
    208
  • cDNA Data
    54
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18479 NCBI Gene Model | MGI Sequence Detail 123841 C57BL/6J ±  kb
    transcript NM_001357365 RefSeq | MGI Sequence Detail 3287 ZRU/MplStud  
    polypeptide O88643 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 54
      Primer pair 3
      Antibodies 14

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1203486, MGI:2142185
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 41
      Gene Ontology 33
      Phenotypes 70
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:388828 Deng SM, et al., ARHGAP39 plays an essential role in anxiety-like behavior and stress response. Transl Psychiatry. 2026 May 9;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory