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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bmpr1a
bone morphogenetic protein receptor, type 1A
MGI:1338938
142 phenotypes from 6 alleles in 21 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		male pseudohermaphroditism J:89999
secondary sex reversal J:89999
Bmpr1atm1Bhr/Bmpr1a+
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal neural tube morphology J:163739
abnormal tail morphology J:163739
Bmpr1atm1Bhr/Bmpr1atm1Bhr
129S7/SvEvBrd-Bmpr1atm1Bhr 		abnormal embryonic tissue morphology J:30426
abnormal embryonic-extraembryonic boundary morphology J:30426
abnormal visceral endoderm morphology J:30426
absent mesoderm J:30426
decreased embryo size J:30426
decreased embryonic epiblast cell proliferation J:30426
embryonic lethality between implantation and somite formation, complete penetrance J:30426
failure of primitive streak formation J:30426
increased embryonic epiblast cell apoptosis J:30426
thick embryonic epiblast J:30426
Bmpr1atm1Bhr/Bmpr1atm1Bhr
B6.129S7-Bmpr1atm1Bhr 		abnormal embryonic tissue morphology J:30426
abnormal embryonic-extraembryonic boundary morphology J:30426
abnormal visceral endoderm morphology J:30426
absent mesoderm J:30426
decreased embryo size J:30426
decreased embryonic epiblast cell proliferation J:30426
embryonic lethality between implantation and somite formation, complete penetrance J:30426
failure of primitive streak formation J:30426
increased embryonic epiblast cell apoptosis J:30426
thick embryonic epiblast J:30426
Bmpr1atm1Bhr/Bmpr1atm1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		abnormal embryonic tissue morphology J:30426
abnormal embryonic-extraembryonic boundary morphology J:30426
abnormal visceral endoderm morphology J:30426
absent mesoderm J:30426
decreased embryo size J:30426
decreased embryonic epiblast cell proliferation J:30426
embryonic lethality between implantation and somite formation, complete penetrance J:30426
failure of primitive streak formation J:30426
increased embryonic epiblast cell apoptosis J:30426
thick embryonic epiblast J:30426
Bmpr1atm1Bhr/Bmpr1atm1Bhr
involves: 129S7/SvEvBrd * Swiss 		abnormal embryonic tissue morphology J:30426
abnormal embryonic-extraembryonic boundary morphology J:30426
abnormal visceral endoderm morphology J:30426
absent mesoderm J:30426
decreased embryo size J:30426
decreased embryonic epiblast cell proliferation J:30426
embryonic lethality between implantation and somite formation, complete penetrance J:30426
failure of primitive streak formation J:30426
increased embryonic epiblast cell apoptosis J:30426
thick embryonic epiblast J:30426
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		normal skeleton phenotype J:169133
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Cga-cre)3Sac/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal heart morphology J:121318
abnormal pituitary gland development J:121318
abnormal Rathke's pouch development J:121318
decreased embryo size J:121318
embryonic lethality during organogenesis, complete penetrance J:121318
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(GATA6-cre)#Jbeb/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal impulse conducting system conduction J:111392
abnormal mitral valve cusp morphology J:111392
abnormal tricuspid valve cusp morphology J:111392
abnormal tricuspid valve morphology J:111392
absent PR interval J:111392
decreased cardiac muscle contractility J:111392
Ebstein's malformation of tricuspid valve J:111392
mitral valve regurgitation J:111392
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Pou3f4-cre)32Cren/0
involves: 129S7/SvEvBrd * CD-1 		abnormal digit morphology J:73526
abnormal hindlimb morphology J:73526
absent hindlimb J:73526
ectopic digits J:73526
polydactyly J:73526
syndactyly J:73526
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Sftpc-cre)1Blh/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR 		abnormal lung epithelium morphology J:106392
abnormal lung morphology J:106392
abnormal respiratory system physiology J:106392
decreased type II pneumocyte number J:106392
postnatal lethality, complete penetrance J:106392
respiratory distress J:106392
normal respiratory system phenotype J:106392
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Six3-cre)69Frty/0
Not Specified 		normal vision/eye phenotype J:96964
Bmpr1atm1Bhr/Bmpr1atm2Bhr
Tg(Pou3f4-cre)32Cren/?
involves: 129S7/SvEvBrd * C57BL/6 * CD-1 		abnormal hair follicle dermal papilla morphology J:91054
abnormal hair follicle morphology J:91054
abnormal hair follicle orientation J:91054
abnormal hair growth J:91054
abnormal hair shaft morphology J:91054
alopecia J:91054
postnatal lethality, complete penetrance J:91054
small hair follicles J:91054
Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Pou3f4-cre)32Cren/0
involves: 129S7/SvEvBrd * CD-1 		no abnormal phenotype detected J:73526
Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 		normal respiratory system phenotype J:106392
Bmpr1atm2.1Bhr/Bmpr1a+
Tg(Sftpc-cre)1Blh/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR 		abnormal lung morphology J:106392
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Kdrtm1(cre)Sato/Kdr+
involves: 129S1/Sv * 129S7/SvEvBrd 		abnormal vascular branching morphogenesis J:112269
abnormal vascular development J:112269
abnormal vein morphology J:112269
abnormal visceral yolk sac morphology J:112269
abnormal vitelline vasculature morphology J:112269
absent atrioventricular cushions J:112269
decreased embryo size J:112269
embryonic growth arrest J:112269
embryonic lethality during organogenesis, complete penetrance J:112269
normal hematopoietic system phenotype J:112269
hemorrhage J:112269
internal hemorrhage J:112269
pale yolk sac J:112269
pallor J:112269
pericardial effusion J:112269
small heart J:112269
vascular smooth muscle hypoplasia J:112269
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Krt14tm1.1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		normal neoplasm J:199091
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Shhtm1(EGFP/cre)Cjt/?
involves: 129S7/SvEvBrd 		preweaning lethality, complete penetrance J:166768
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal gastric gland morphology J:163367
abnormal pyloric gastric gland morphology J:163367
abnormal stomach epithelium morphology J:163367
abnormal submucosal gland morphology J:163367
alopecia J:163367
gastric polyps J:163367
stomach inflammation J:163367
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Tg(Col1a1-cre/Esr1*)1Mis/0
involves: 129S7/SvEvBrd 		abnormal bone structure J:143588
abnormal osteoclast differentiation J:143588
abnormal osteoclast physiology J:143588
abnormal skeleton morphology J:143588
abnormal skeleton physiology J:143588
decreased bone ossification J:143588
decreased osteoclast cell number J:143588
enlarged parietal bone J:143588
increased bone mass J:143588
increased bone mineralization J:143588
Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr
Tg(Col2a1-cre)1Bhr/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal thoracic cage shape J:97410
chondrodystrophy J:97410
decreased length of long bones J:97410
delayed bone ossification J:97410
postnatal lethality J:97410
respiratory distress J:97410
small thoracic cage J:97410
Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr
Isl1tm1(cre)Sev/Isl1+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal cardiomyocyte apoptosis J:107396
abnormal fetal cardiomyocyte proliferation J:107396
abnormal hindlimb bud morphology J:107396
abnormal hindlimb morphology J:107396
decreased cell proliferation J:107396
embryonic lethality during organogenesis, complete penetrance J:107396
persistent truncus arteriosus J:107396
small hindlimb buds J:107396
Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr
Tg(Gdf5-cre,-ALPP)1Kng/0
involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng 		abnormal articular cartilage morphology J:97780
abnormal cartilage development J:97780
abnormal ear shape J:97780
abnormal long bone epiphysis morphology J:97780
abnormal skeleton development J:97780
abnormal synovial joint membrane morphology J:97780
decreased grip strength J:97780
decreased joint mobility J:97780
fused joints J:97780
osteoarthritis J:97780
osteosclerosis J:97780
short ears J:97780
syndactyly J:97780
Bmpr1atm2.2Bhr/Bmpr1atm2.2Bhr
involves: 129S7/SvEvBrd 		prenatal lethality J:75074
Bmpr1atm2Bhr/Bmpr1atm2Bhr
Tg(KRT14-cre)40Smr/?
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J 		abnormal hair follicle dermal papilla morphology J:91054
abnormal hair follicle morphology J:91054
abnormal hair follicle orientation J:91054
abnormal hair follicle regression J:91054
abnormal hair growth J:91054
abnormal hair shaft morphology J:91054
abnormal nail morphology J:91054
abnormal tooth morphology J:91054
absent teeth J:91054
alopecia J:91054
decreased body size J:91054
premature death J:91054
small hair follicles J:91054
Bmpr1atm2Bhr/Bmpr1atm2Bhr
Tg(KRT14-cre)43Smr/?
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J 		abnormal mouth morphology J:91054
abnormal suckling behavior J:91054
abnormal tooth development J:91054
absent hindlimb J:91054
absent teeth J:91054
eyelids open at birth J:91054
increased hair follicle number J:91054
neonatal lethality, complete penetrance J:91054
Bmpr1atm2Bhr/Bmpr1atm2Bhr
Tg(KRT14-cre)52Smr/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J 		abnormal hair follicle dermal papilla morphology J:91054
abnormal hair follicle morphology J:91054
abnormal hair follicle orientation J:91054
abnormal hair growth J:91054
abnormal hair shaft morphology J:91054
abnormal mouth morphology J:91054
abnormal suckling behavior J:91054
absent teeth J:91054
alopecia J:91054
decreased body size J:91054
postnatal lethality, complete penetrance J:91054
small hair follicles J:91054
Bmpr1atm2Bhr/Bmpr1atm2Bhr
Tg(KRT14-cre/ERT2)1Ipc/?
involves: 129S7/SvEvBrd * C57BL/6 		abnormal hair follicle morphology J:91054
abnormal hair growth J:91054
abnormal nail morphology J:91054
premature death J:91054
preneoplasia J:91054
sparse hair J:91054
Gt(ROSA)26Sortm1(CAG-Bmpr1a)Que/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/?
Not Specified 		abnormal esophageal epithelium morphology J:166768
abnormal forestomach morphology J:166768
preweaning lethality, complete penetrance J:166768
Tg(CAG-Bmpr1a*,-lacZ)1Nobs/Tg(CAG-Bmpr1a*,-lacZ)1Nobs
B6.Cg-Tg(CAG-Bmpr1a*,-lacZ)1Nobs 		no abnormal phenotype detected J:192670
Tg(CAG-Bmpr1a*,-lacZ)1Nobs/0
Tg(Mpz-cre)94Imeg/0
involves: 129X1/SvJ * C57BL/6J 		abnormal bone ossification J:192670
abnormal craniofacial development J:192670
abnormal facial morphology J:192670
abnormal frontonasal mesenchyme morphology J:192670
abnormal head mesenchyme morphology J:192670
abnormal nasal bone morphology J:192670
abnormal nasal septum morphology J:192670
abnormal neurocranium morphology J:192670
abnormal suckling behavior J:192670
belly spot J:192670
cleft palate J:192670
decreased survivor rate J:192670
facial cleft J:192670
large anterior fontanelle J:192670
midline facial cleft J:192670
neonatal lethality, incomplete penetrance J:192670
ocular hypertelorism J:192670
short face J:192670
small frontal bone J:192670
ventricular septal defect J:192670
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04/23/2024
MGI 6.23 		The Jackson Laboratory