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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sh2d1a
SH2 domain containing 1A
MGI:1328352
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Faslpr/\Faslpr
\Sh2d1arpl/\Sh2d1arpl
MRL/Mp-Faslpr Sh2d1arpl 		abnormal immune system physiology J:126261
increased anti-nuclear antigen antibody level J:126261
\Sh2d1atm1.1Knic/Y
\Gt(ROSA)26Sortm1(EYFP)Cos/\Gt(ROSA)26Sor+
\Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal NK T cell physiology J:196692
decreased circulating interleukin-4 level J:196692
decreased interferon-gamma secretion J:196692
normal immune system phenotype J:196692
\Sh2d1atm1.1Knic/\Sh2d1atm1.1Knic
\Gt(ROSA)26Sortm1(EYFP)Cos/\Gt(ROSA)26Sor+
\Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal NK T cell physiology J:196692
decreased circulating interleukin-4 level J:196692
decreased interferon-gamma secretion J:196692
normal immune system phenotype J:196692
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
\Sh2d1b1/Sh2d1b2tm1.1Cpt/\Sh2d1b1/Sh2d1b2tm1.1Cpt
involves: 129S4/SvJae * BALB/cJ 		impaired natural killer cell mediated cytotoxicity J:166054
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
\Sh2d1b1/Sh2d1b2tm1.1Cpt/\Sh2d1b1/Sh2d1b2tm1.1Cpt
involves: 129S4/SvJae * BALB/cJ 		impaired natural killer cell mediated cytotoxicity J:166054
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
\Tcra-Jtm1Tgi/\Tcra-Jtm1Tgi
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		decreased germinal center B cell number J:189126
decreased IgG level J:189126
\Sh2d1atm1Cpt/Y
\Tcra-Jtm1Tgi/\Tcra-Jtm1Tgi
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c 		decreased germinal center B cell number J:189126
decreased IgG level J:189126
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Sh2d1b1tm3Vei/\Sh2d1b1tm3Vei
involves: 129S6/SvEvTac * C57BL/6 		abnormal NK cell physiology J:187430
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Slamf6tm1Lex/\Slamf6tm1Lex
B6.129S-Slamf6tm1Lex Sh2d1atm1Pls 		normal immune system phenotype J:187429
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Slamf6tm1Pls/\Slamf6tm1Pls
\Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J 		normal immune system phenotype J:187431
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Tg(DO11.10)10Dlo/\Tg(DO11.10)10Dlo
involves: BALB/c * C3H * C57BL/6 		abnormal cytokine secretion J:90484
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Tg(TcraTcrb)425Cbn/?
involves: 129S6/SvEvTac * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:157915
\Sh2d1atm1Pls/\Sh2d1atm1Pls
\Tg(TcraTcrb)1100Mjb/0
involves: 129S6/SvEvTac * C57BL/6 		abnormal cytotoxic T cell physiology J:187431
decreased cytotoxic T cell cytolysis J:187431
decreased interferon-gamma secretion J:187431
\Sh2d1atm1Vei/\Sh2d1atm1Vei
\Sh2d1b1tm3Vei/\Sh2d1b1tm3Vei
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal NK cell physiology J:187430
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory