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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sh2d1a
SH2 domain containing 1A
MGI:1328352
44 phenotypes from 8 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Sh2d1atm1Cpt/Y
involves: 129S4/SvJae * BALB/c 		abnormal cytokine secretion J:97756
abnormal germinal center B cell morphology J:189126
decreased germinal center B cell number J:189126
decreased IgE level J:97756
decreased IgG level J:189126
decreased NK T cell number J:189126
decreased susceptibility to parasitic infection J:97756
normal immune system phenotype J:189126
\Sh2d1atm1Cpt/\Sh2d1a+
involves: 129S4/SvJae * C57BL/6 		abnormal cytokine secretion J:97756
increased T cell proliferation J:97756
\Sh2d1atm1Cpt/Y
involves: 129S4/SvJae * C57BL/6 		abnormal cytokine secretion J:97756
abnormal germinal center B cell physiology J:189126
abnormal humoral immune response J:189126
abnormal immunoglobulin level J:189126
abnormal NK T cell physiology J:189126
decreased NK T cell number J:189126
increased susceptibility to Riboviria infection J:97756
increased T cell proliferation J:97756
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
B6.129S4-Sh2d1atm1Cpt 		abnormal humoral immune response J:97388
absent NK T cells J:97690
decreased IgG1 level J:97388
decreased IgM level J:97388
decreased NK T cell number J:97690
decreased transitional stage B cell number J:97690
increased B cell number J:97388
increased IgG2a level J:97388
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
C.129S4-Sh2d1atm1Cpt 		decreased IgG level J:97388
decreased IgM level J:97388
decreased spleen germinal center number J:97388
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
involves: 129S4/SvJae 		impaired natural killer cell mediated cytotoxicity J:166054
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
involves: 129S4/SvJae * BALB/c 		abnormal cytokine secretion J:97756
abnormal germinal center B cell morphology J:189126
decreased germinal center B cell number J:189126
decreased IgE level J:97756
decreased IgG level J:189126
decreased NK T cell number J:189126
decreased susceptibility to parasitic infection J:97756
normal immune system phenotype J:189126
\Sh2d1atm1Cpt/\Sh2d1atm1Cpt
involves: 129S4/SvJae * C57BL/6 		abnormal cytokine secretion J:97756
abnormal germinal center B cell physiology J:189126
abnormal humoral immune response J:189126
abnormal immunoglobulin level J:189126
abnormal NK T cell physiology J:189126
decreased NK T cell number J:189126
increased susceptibility to Riboviria infection J:97756
increased T cell proliferation J:97756
\Sh2d1atm1Lyin/Y
involves: 129S2/SvPas * C57BL/6 		abnormal immune system physiology J:97346
chronic inflammation J:97346
decreased IgE level J:97346
decreased IgG level J:97346
decreased immunoglobulin level J:97346
increased CD8-positive, alpha-beta T cell number J:97346
\Sh2d1atm1Lyin/\Sh2d1atm1Lyin
involves: 129S1/Sv * 129X1/SvJ 		impaired natural killer cell mediated cytotoxicity J:110195
\Sh2d1atm1Lyin/\Sh2d1atm1Lyin
involves: 129S2/SvPas * C57BL/6 		abnormal immune system physiology J:97346
chronic inflammation J:97346
decreased IgE level J:97346
decreased IgG level J:97346
decreased immunoglobulin level J:97346
increased CD8-positive, alpha-beta T cell number J:97346
\Sh2d1atm1Pls/Y
involves: 129S6/SvEvTac 		abnormal CD4-positive, alpha-beta T cell physiology J:157915
abnormal cytotoxic T cell physiology J:187431
abnormal long lived plasma cell morphology J:157915
abnormal NK T cell morphology J:196692
decreased CD4-positive, alpha-beta T cell number J:157915
decreased IgG level J:157915
decreased interleukin-21 secretion J:157915
\Sh2d1atm1Pls/\Sh2d1atm1Pls
B6.129S6-Sh2d1atm1Pls 		abnormal CD4-positive, alpha-beta T cell physiology J:93886
abnormal NK cell physiology J:187430
decreased IgE level J:93886
decreased interferon-gamma secretion J:187430
\Sh2d1atm1Pls/\Sh2d1atm1Pls
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal lymphocyte cell number J:70032
abnormal T-helper 1 cell morphology J:70032
abnormal T-helper 2 cell morphology J:70032
decreased IgE level J:70032
increased susceptibility to infection J:70032
increased susceptibility to parasitic infection J:70032
increased susceptibility to Riboviria infection J:70032
increased T cell proliferation J:70032
\Sh2d1atm1Pls/\Sh2d1atm1Pls
involves: 129S6/SvEvTac 		abnormal CD4-positive, alpha-beta T cell physiology J:157915
abnormal cytotoxic T cell physiology J:187431
abnormal long lived plasma cell morphology J:157915
abnormal NK T cell morphology J:196692
decreased CD4-positive, alpha-beta T cell number J:157915
decreased IgG level J:157915
decreased interleukin-21 secretion J:157915
\Sh2d1atm1Pls/\Sh2d1atm1Pls
involves: 129S6/SvEvTac * C57BL/6 		normal immune system phenotype J:92740
\Sh2d1atm1Pls/\Sh2d1atm1Pls
involves: BALB/c 		decreased susceptibility to parasitic infection J:90484
\Sh2d1atm1Vei/\Sh2d1atm1Vei
B6.129-Sh2d1atm1Vei 		abnormal NK cell physiology J:187430
decreased interferon-gamma secretion J:187430
\Sh2d1atm1Vei/\Sh2d1atm1Vei
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:93886
abnormal memory T cell physiology J:93886
decreased IgE level J:93886
\Sh2d1atm2.1Cpt/Y
\Gt(ROSA)26Sortm9(cre/ESR1)Arte/\Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac 		abnormal germinal center B cell physiology J:189126
abnormal humoral immune response J:189126
decreased IgG level J:189126
decreased IgM level J:189126
normal immune system phenotype J:189126
\Sh2d1atm2.1Cpt/\Sh2d1atm2.1Cpt
\Gt(ROSA)26Sortm9(cre/ESR1)Arte/\Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac 		abnormal germinal center B cell physiology J:189126
abnormal humoral immune response J:189126
decreased IgG level J:189126
decreased IgM level J:189126
normal immune system phenotype J:189126
\Sh2d1atm2.1Vei/\Sh2d1atm2.1Vei
involves: C57BL/6 		decreased germinal center B cell number J:131618
decreased IgE level J:131618
decreased IgG1 level J:131618
decreased IgG2a level J:131618
decreased IgG2b level J:131618
decreased IgG3 level J:131618
decreased IgM level J:131618
decreased NK T cell number J:131618
\Sh2d1atm2Vei/\Sh2d1atm2Vei
\Cd19tm1(cre)Cgn/\Cd19+
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:131618
\Sh2d1atm2Vei/\Sh2d1atm2Vei
\Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased germinal center B cell number J:131618
decreased IgE level J:131618
decreased IgG1 level J:131618
decreased IgG2a level J:131618
decreased IgG2b level J:131618
decreased IgG3 level J:131618
decreased IgM level J:131618
decreased NK T cell number J:131618
\Sh2d1atm2Vei/\Sh2d1atm2Vei
\Tg(Lck-cre)1Cwi/0
involves: C57BL/6 		decreased germinal center B cell number J:131618
decreased IgE level J:131618
decreased IgG1 level J:131618
decreased IgG2a level J:131618
decreased IgG2b level J:131618
decreased IgG3 level J:131618
decreased IgM level J:131618
decreased NK T cell number J:131618
\Tg(CD2-Sh2d1a)#Vei/0
involves: 129S1/Sv * 129X1/SvJ 		increased natural killer cell mediated cytotoxicity J:110195
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory