Sh2d1a^tm2.1Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1a^tm2.1Vei
• Name: SH2 domain containing 1A; targeted mutation 2.1, Andre Veillette
• MGI ID: MGI:3775432
• Synonyms: sap^-
• Gene: Sh2d1a Location: ChrX:41591442-41610974 bp, + strand Genetic Position: ChrX, 23.2 cM, cytoband A5
• Alliance: Sh2d1a^tm2.1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed by germ-line cre-mediated recombination. Authors state that this is a null allele. (J:131618)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1a Mutation: 10 strains or lines available

References

• Original: J:131618 Veillette A, et al., SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1273-8
• All: 5 reference(s)