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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bscl2
BSCL2 lipid droplet biogenesis associated, seipin
MGI:1298392
121 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bscl2tm1.1Gliu/Bscl2tm1.1Gliu
Tg(Ddx4-cre)1Dcas/0
involves: 129 * 129S4/SvJaeSor * FVB/N 		abnormal male germ cell morphology J:211072
abnormal phospholipid level J:211072
abnormal sperm flagellum morphology J:211072
abnormal sperm head morphology J:211072
abnormal spermatid morphology J:211072
abnormal spermatogenesis J:211072
abnormal spermiogenesis J:211072
abnormal testis morphology J:211072
normal adipose tissue phenotype J:211072
asthenozoospermia J:211072
normal homeostasis/metabolism phenotype J:211072
male infertility J:211072
oligozoospermia J:211072
teratozoospermia J:211072
Bscl2tm1.1Gliu/Bscl2tm1.1Gliu
Tg(Fabp4-cre)1Rev/0
involves: 129 * 129S4/SvJaeSor 		increased circulating cholesterol level J:211072
increased circulating insulin level J:211072
lipodystrophy J:211072
normal reproductive system phenotype J:211072
Bscl2tm1.1Lchan/Bscl2tm1.1Lchan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal aerobic respiration J:183701
abnormal cellular respiration J:183701
abnormal epididymal fat pad morphology J:211142
abnormal fat cell differentiation J:183701
abnormal fat pad morphology J:183701
abnormal glucose homeostasis J:183701
abnormal lipid homeostasis J:183701
abnormal lipid metabolism J:211142
abnormal small intestine morphology J:183701
abnormal white adipose tissue amount J:183701
abnormal white adipose tissue morphology J:211142
abnormal white adipose tissue physiology J:211142
abnormal white fat cell morphology J:183701
decreased body size J:183701
decreased body weight J:183701
decreased brown adipose tissue amount J:183701
decreased circulating adiponectin level J:183701
decreased circulating free fatty acids level J:183701
decreased circulating glucose level J:183701
decreased circulating glycerol level J:183701
decreased circulating leptin level J:183701
decreased circulating triglyceride level J:183701
decreased gonadal fat pad weight J:183701
decreased interscapular fat pad weight J:183701
decreased renal fat pad weight J:183701
decreased subcutaneous adipose tissue amount J:183701
decreased total body fat amount J:183701
decreased white adipose tissue amount J:211142
decreased white fat cell number J:183701
decreased white fat cell size J:183701
enhanced lipolysis J:183701
enlarged heart J:183701
enlarged kidney J:183701
enlarged liver J:183701
enlarged spleen J:183701
hepatic steatosis J:183701
increased circulating free fatty acids level J:183701
increased circulating glucose level J:183701
increased circulating glycerol level J:183701
increased circulating insulin level J:183701
increased circulating triglyceride level J:183701
increased lean body mass J:183701
insulin resistance J:183701
polyphagia J:183701
postnatal lethality, incomplete penetrance J:183701
Bscl2tm1.2Gliu/Bscl2tm1.2Gliu
involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal epididymal fat pad morphology J:173404
abnormal hypodermis fat layer morphology J:173404
abnormal male germ cell morphology J:211072
abnormal phospholipid level J:211072
abnormal sperm flagellum morphology J:211072
abnormal sperm head morphology J:211072
abnormal spermatid morphology J:211072
abnormal spermatogenesis J:211072
abnormal spermiogenesis J:211072
abnormal testis morphology J:211072
abnormal white fat cell differentation J:173404
asthenozoospermia J:211072
decreased body size J:173404
decreased brown adipose tissue amount J:173404
decreased circulating adiponectin level J:173404
decreased circulating leptin level J:173404
decreased gonadal fat pad weight J:173404
decreased inguinal fat pad weight J:173404
decreased mesenteric fat pad weight J:173404
decreased retroperitoneal fat pad weight J:173404
decreased subcutaneous adipose tissue amount J:173404
decreased total body fat amount J:173404
enlarged liver J:173404
enlarged spleen J:173404
impaired glucose tolerance J:173404
increased body temperature J:173404
increased circulating cholesterol level J:173404, J:211072
increased circulating glucose level J:173404
increased circulating insulin level J:173404, J:211072
increased circulating triglyceride level J:173404
increased liver triglyceride level J:173404
insulin resistance J:173404
lipodystrophy J:211072
normal liver/biliary system phenotype J:173404
macrovesicular hepatic steatosis J:173404
male infertility J:211072
microvesicular hepatic steatosis J:173404
oligozoospermia J:211072
teratozoospermia J:211072
Bscl2tm1b(EUCOMM)Hmgu/Bscl2tm1b(EUCOMM)Hmgu
C57BL/6N-Bscl2tm1b(EUCOMM)Hmgu/Ics 		abnormal bone structure J:211773
abnormal gait J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased erythrocyte cell number J:211773
decreased locomotor activity J:211773
decreased prepulse inhibition J:211773
decreased respiratory quotient J:211773
decreased total body fat amount J:211773
decreased total retina thickness J:211773
improved glucose tolerance J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating calcium level J:211773
increased circulating cholesterol level J:211773
increased circulating glucose level J:211773
increased circulating HDL cholesterol level J:211773
increased circulating phosphate level J:211773
increased circulating serum albumin level J:211773
increased circulating total protein level J:211773
increased cornea thickness J:211773
increased fasting circulating glucose level J:211773
increased fluid intake J:211773
increased food intake J:211773
increased large unstained cell number J:211773
increased lean body mass J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
short tibia J:211773
Bscl2tm1c(EUCOMM)Hmgu/Bscl2tm1c(EUCOMM)Hmgu
Tg(Adipoq-cre)1Evdr/0
involves: C57BL/6N * FVB/NJ 		abnormal brown adipose tissue morphology J:260853
abnormal infrapatellar fat pad morphology J:260853
abnormal triglyceride level J:260853
abnormal white adipose tissue morphology J:260853
browned white adipose tissue morphology J:260853
decreased body fat mass J:260853
decreased bone marrow adipose tissue amount J:260853
decreased brown adipose tissue mass J:260853
decreased circulating adiponectin level J:260853
decreased locomotor activity J:260853
decreased respiratory quotient J:260853
decreased subcutaneous adipose tissue amount J:260853
decreased susceptibility to diet-induced obesity J:260853
decreased white adipose tissue amount J:260853
normal homeostasis/metabolism phenotype J:260853
increased lean body mass J:260853
increased liver triglyceride level J:260853
increased respiratory quotient J:260853
lipodystrophy J:260853
Bscl2tm1Geno/Bscl2tm1Geno
B6.129P2-Bscl2tm1Geno 		abnormal adipose tissue development J:200947
abnormal epididymis morphology J:200947
abnormal intestine morphology J:200947
abnormal lipid homeostasis J:200947
normal behavior/neurological phenotype J:200947
decreased body weight J:200947
decreased carbon dioxide production J:200947
decreased circulating adiponectin level J:200947
decreased circulating free fatty acids level J:200947
decreased circulating leptin level J:200947
decreased circulating triglyceride level J:200947
decreased energy expenditure J:200947
decreased gonadal fat pad weight J:200947
decreased inguinal fat pad weight J:200947
decreased interscapular fat pad weight J:200947
decreased mesenteric fat pad weight J:200947
decreased oxygen consumption J:200947
enhanced lipolysis J:200947
enlarged liver J:200947
hepatic steatosis J:200947
normal homeostasis/metabolism phenotype J:200947
hyperglycemia J:200947
impaired glucose tolerance J:200947
increased brown adipose tissue amount J:200947
increased circulating glucose level J:200947
increased circulating HDL cholesterol level J:200947
increased circulating insulin level J:200947
increased food intake J:200947
increased liver triglyceride level J:200947
increased liver weight J:200947
insulin resistance J:200947
lipodystrophy J:200947
male infertility J:200947
preweaning lethality, incomplete penetrance J:200947
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory