Bscl2tm1.2Gliu
Targeted Allele Detail
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Symbol: |
Bscl2tm1.2Gliu |
Name: |
BSCL2 lipid droplet biogenesis associated, seipin; targeted mutation 1.2, George Liu |
MGI ID: |
MGI:5014325 |
Synonyms: |
seipin- |
Gene: |
Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
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Alliance: |
Bscl2tm1.2Gliu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:173404
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp- and cre-mediated recombination removed the neo cassette and exon 3, respectively. The absence of transcript expression was confirmed by qRT-PCR on white adipose tissue, brown adipose tissue, bone marrow, liver, kidney, and skeletal muscle extracts.
(J:173404)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bscl2 Mutation: |
33 strains or lines available
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Original: |
J:173404 Cui X, et al., Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet. 2011 Aug 1;20(15):3022-30 |
All: |
17 reference(s) |
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