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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Phox2b
paired-like homeobox 2b
MGI:1100882
75 phenotypes from 10 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Egr2tm2(cre)Pch/Egr2+
Phox2btm4Jbr/Phox2b+
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal autonomic nervous system physiology J:176573
abnormal respiratory function J:176573
abnormal retrotrapezoid nucleus morphology J:176573
alkalemia J:176573
decreased pulmonary ventilation J:176573
normal mortality/aging J:176573
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3.1Jbr/Phox2btm3.1Jbr
involves: 129S2/SvPas * 129X1/SvJ 		abnormal pterygopalatine ganglion morphology J:157532
absent petrosal ganglion J:157532
Phox2bDilp1/Phox2b+
involves: BALB/cAnN * C3H/HeN 		abnormal ciliary ganglion morphology J:91199
abnormal eye morphology J:75964
impaired pupillary reflex J:91199
mydriasis J:75964, J:91199
preweaning lethality, incomplete penetrance J:75964
Phox2bDilp1/Phox2bDilp1
involves: BALB/cAnN * C3H/HeN 		postnatal lethality J:75964
Phox2bem3(cre)Heno/Phox2b+
involves: 129 * C57BL/6 * C57BL/6N * DBA 		postnatal growth retardation J:344865
Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
involves: 129S4/SvJae 		abnormal cardiovascular system morphology J:126634
abnormal cranial ganglia morphology J:126634
abnormal enteric nervous system morphology J:126634
abnormal locus ceruleus morphology J:126634
abnormal motor neuron morphology J:126634
abnormal nervous system morphology J:126634
abnormal noradrenaline level J:126634
abnormal parasympathetic ganglion morphology J:126634
abnormal vagus ganglion morphology J:126634
embryonic lethality during organogenesis, complete penetrance J:126634
small facial motor nucleus J:126634
small trigeminal ganglion J:126634
Phox2btm1.1Heno/Phox2b+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) 		abnormal enteric ganglia morphology J:190742
abnormal enteric neural crest cell migration J:190742
abnormal glial cell morphology J:190742
abnormal neuron physiology J:190742
abnormal neuronal precursor proliferation J:190742
abnormal respiratory function J:190742
abnormal retrotrapezoid nucleus morphology J:190742
abnormal sympathetic ganglion morphology J:190742
abnormal vagus ganglion morphology J:190742
cyanosis J:190742
decreased enteric neural crest cell number J:190742
decreased enteric neural crest cell proliferation J:190742
decreased neuronal precursor cell number J:190742
impaired neuron differentiation J:190742
neonatal lethality, complete penetrance J:190742
small facial motor nucleus J:190742
Phox2btm1Jbr/Phox2b+
Not Specified 		abnormal ciliary ganglion morphology J:91199
abnormal pulmonary ventilation J:86516
decreased pulmonary ventilation J:86516
impaired pupillary reflex J:91199
mydriasis J:91199
Phox2btm1Jbr/Phox2btm1Jbr
Not Specified 		abnormal area postrema morphology J:86516
abnormal autonomic nervous system morphology J:55391
abnormal carotid body morphology J:86516
abnormal cranial ganglia morphology J:55391, J:86516
abnormal cranial nerve morphology J:60832
abnormal enteric ganglia morphology J:55391
abnormal geniculate ganglion morphology J:55391, J:86516
abnormal glossopharyngeal ganglion morphology J:55391
abnormal locus ceruleus morphology J:63723
abnormal medulla oblongata morphology J:86516
abnormal motor neuron morphology J:55391, J:60832
abnormal nodose ganglion morphology J:86516
abnormal noradrenaline level J:55391, J:63723
abnormal parasympathetic ganglion morphology J:55391
abnormal petrosal ganglion morphology J:86516
abnormal sympathetic ganglion morphology J:55391
abnormal vagus ganglion morphology J:55391
abnormal vagus nerve morphology J:60832
absent facial nerve J:60832
absent trigeminal nerve J:60832
blood vessel congestion J:63723
embryonic lethality during organogenesis, incomplete penetrance J:63723
lethality throughout fetal growth and development, complete penetrance J:63723
Phox2btm1Rth/Phox2b+
Hprt1tm1(CAG-cre)Mnn/?
involves: 129 * 129S1/Sv * C57BL/6 		abnormal facial nerve morphology J:331513
abnormal innervation J:331513
abnormal locus ceruleus morphology J:331513
abnormal nervous system electrophysiology J:331513
abnormal neuron morphology J:331513
abnormal trigeminal V mesencephalic nucleus morphology J:331513
abnormal vagus nerve morphology J:331513
cyanosis J:331513
perinatal lethality, complete penetrance J:331513
respiratory failure J:331513
Phox2btm1Rth/Phox2b+
Tg(Fabp7-cre,-lacZ)3Gtm/0
involves: 129 * C57BL/6 * CBA 		abnormal facial nerve morphology J:331513
abnormal retrotrapezoid nucleus morphology J:331513
abnormal suckling behavior J:331513
decreased pulmonary respiratory rate J:331513
normal nervous system phenotype J:331513
Phox2btm2.1Heno/Phox2b+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2) 		abnormal enteric ganglia morphology J:190742
abnormal enteric neural crest cell migration J:190742
abnormal glial cell morphology J:190742
abnormal neuron physiology J:190742
abnormal neuronal precursor proliferation J:190742
abnormal respiratory function J:190742
abnormal retrotrapezoid nucleus morphology J:190742
abnormal sympathetic ganglion morphology J:190742
cyanosis J:190742
decreased enteric neural crest cell number J:190742
decreased enteric neural crest cell proliferation J:190742
decreased neuronal precursor cell number J:190742
impaired neuron differentiation J:190742
neonatal lethality, complete penetrance J:190742
Phox2btm2Jbr/Phox2b+
involves: 129S2/SvPas 		abnormal neuron physiology J:155885
Phox2btm2Jbr/Phox2b+
involves: 129S2/SvPas * C57BL/6 		abnormal brain interneuron morphology J:131365
abnormal breathing pattern J:131365
abnormal lung volume J:131365
abnormal respiration J:131365
apnea J:131365
cyanosis J:131365
hypoventilation J:131365
neonatal lethality, complete penetrance J:131365
respiratory failure J:131365
Phox2btm3.1Jbr/Phox2btm3.1Jbr
involves: 129S2/SvPas * C57BL/6 * DBA/2 		no abnormal phenotype detected J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Egr2tm2(cre)Pch/Egr2+
involves: 129S2/SvPas * C57BL/6 * DBA/2 		abnormal neuron differentiation J:155885
abnormal neuron physiology J:155885
postnatal lethality, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * C57BL/6J * CBA/J 		abnormal parasympathetic ganglion morphology J:157532
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Isl1tm1(cre)Tmj/Isl1+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal neuron differentiation J:155885
abnormal neuron physiology J:155885
decreased body size J:155885
postnatal lethality, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 		embryonic lethality during organogenesis, complete penetrance J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 		abnormal nervous system morphology J:155885
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * CD-1 		abnormal motor neuron morphology J:157532
normal nervous system phenotype J:157532
Phox2btm4Jbr/Phox2b+
Tg(Pou3f4-cre)32Cren/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 		neonatal lethality, complete penetrance J:176573
Phox2btm4Jbr/Phox2b+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal respiration J:155885
Phox2btm4Jbr/Phox2b+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6 * DBA/2 		abnormal retrotrapezoid nucleus morphology J:176573
neonatal lethality, complete penetrance J:176573
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory