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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ercc6
excision repair cross-complementing rodent repair deficiency, complementation group 6
MGI:1100494
63 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Gvh/Xpatm1Hvs
Tg(CAG-cre)13Miya/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J 		abnormal gait J:179808
cachexia J:179808
postnatal growth retardation J:179808
postnatal lethality, complete penetrance J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Gvh/Xpatm1Hvs
Tg(Camk2a-cre)1Szi/0
involves: 129P2/OlaHsd * C57BL/6J * CBA 		abnormal cerebral cortex morphology J:179808
abnormal dorsal striatum morphology J:179808
abnormal neocortex morphology J:179808
abnormal telencephalon morphology J:179808
astrocytosis J:179808
decreased body size J:179808
decreased body weight J:179808
dilated lateral ventricle J:179808
hippocampus atrophy J:179808
impaired coordination J:179808
increased thigmotaxis J:179808
microgliosis J:179808
neuron degeneration J:179808
premature death J:179808
seizures J:179808
thin cerebral cortex J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Gvh/Xpatm1Hvs
Tg(Pcp2-cre)2Mpin/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J 		astrocytosis J:179808
axon degeneration J:179808
microgliosis J:179808
Purkinje cell degeneration J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Hvs/Xpatm1Hvs
B6.129P2-Xpatm1Hvs Ercc6tm1Gvh 		abnormal abdominal fat pad morphology J:122013
abnormal epiphyseal plate morphology J:122013
abnormal gait J:122013
abnormal limb posture J:122013
abnormal Purkinje cell morphology J:122013
abnormal retina inner nuclear layer morphology J:122013
abnormal retina morphology J:122013
abnormal retina outer nuclear layer morphology J:122013
ataxia J:122013
dystonia J:122013
hepatic steatosis J:122013
hypoglycemia J:122013
increased cellular sensitivity to gamma-irradiation J:122013
increased liver glycogen level J:122013
kyphosis J:122013
lipodystrophy J:122013
long limbs J:122013
postnatal growth retardation J:122013
premature aging J:122013
retina degeneration J:122013
short stride length J:122013
tremors J:122013
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Hvs/Xpatm1Hvs
involves: 129P2/OlaHsd * C57BL/6J 		abnormal base-excision repair J:122013
cachexia J:122013
disproportionate dwarf J:122013
increased cellular sensitivity to ultraviolet irradiation J:122013
perinatal lethality, incomplete penetrance J:122013
postnatal growth retardation J:122013
postnatal lethality, complete penetrance J:122013
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpatm1Tnka/Xpatm1Tnka
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cerebellar cortex morphology J:72574
abnormal cerebellar Purkinje cell layer J:72574
abnormal cerebellum development J:72574
abnormal gait J:72574
abnormal Purkinje cell dendrite morphology J:72574
ataxia J:72574
decreased brain weight J:72574
decreased cerebellar granule cell precursor proliferation J:72574
impaired balance J:72574
limb grasping J:72574
postnatal lethality, complete penetrance J:72574
reduced cerebellar foliation J:72574
slow postnatal weight gain J:72574
small cerebellum J:72574
thin cerebellar granule layer J:72574
thin cerebellar molecular layer J:72574
tremors J:72574
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpctm1Brd/Xpctm1Brd
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal gait J:182229
abnormal myelin sheath morphology J:182229
abnormal myelination J:182229
abnormal oligodendrocyte physiology J:182229
ataxia J:182229
cachexia J:182229
impaired coordination J:182229
lethality at weaning, complete penetrance J:182229
limb grasping J:182229
postnatal growth retardation J:182229
short stride length J:182229
Ercc6tm1Gvh/Ercc6tm1Gvh
Xpctm1Ecf/Xpctm1Ecf
involves: 129 * 129P2/OlaHsd * C57BL/6J 		abnormal base-excision repair J:122013
cachexia J:122013
disproportionate dwarf J:122013
increased cellular sensitivity to ultraviolet irradiation J:122013
perinatal lethality, incomplete penetrance J:122013
postnatal growth retardation J:122013
postnatal lethality, complete penetrance J:122013
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory