Rgs2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rgs2
regulator of G-protein signaling 2
MGI:1098271

21 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rgs2^em1(IMPC)H/Rgs2⁺ C57BL/6NTac-Rgs2^em1(IMPC)H/H	increased large unstained cell number	J:211773
Rgs2^em1(IMPC)H/Rgs2^em1(IMPC)H C57BL/6NTac-Rgs2^em1(IMPC)H/H	abnormal tooth morphology	J:211773
	decreased fasting circulating glucose level	J:211773
	enlarged spleen	J:211773
Rgs2^tm1.1Kjb/Rgs2^tm1.1Kjb X/Tg(Myh11-icre/ERT2)1Soff involves: 129X1/SvJ * C57BL/6 * FVB/N	normal cardiovascular system phenotype	J:184284
Rgs2^tm1.1Kjb/Rgs2^tm1.1Kjb Tg(Tek-cre/ERT2)1Arnd/? involves: 129X1/SvJ * C57BL/6 * DBA/2	normal cardiovascular system phenotype	J:184284
	decreased vasodilation	J:184284
	increased mean systemic arterial blood pressure	J:184284
Rgs2^tm1Dgen/Rgs2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Rgs2^tm1Pngr/Rgs2⁺ involves: C57BL/6J	abnormal kidney vasculature morphology	J:81893
	increased systemic arterial blood pressure	J:81893
	normal nervous system phenotype	J:81893
Rgs2^tm1Pngr/Rgs2^tm1Pngr B6.129P2-Rgs2^tm1Pngr	decreased vasodilation	J:184284
Rgs2^tm1Pngr/Rgs2^tm1Pngr B6.129P2-Rgs2^tm1Pngr	increased vasoconstriction	J:184284
Rgs2^tm1Pngr/Rgs2^tm1Pngr involves: C57BL/6J	abnormal blood vessel physiology	J:86774
	abnormal hippocampus CA1 region morphology	J:77273
	abnormal kidney vasculature morphology	J:81893
	abnormal nervous system electrophysiology	J:77273
	abnormal T cell proliferation	J:77273
	aortic hypertrophy	J:86774
	normal behavior/neurological phenotype	J:77273
	normal cardiovascular system phenotype	J:86774
	decreased aggression	J:77273
	normal hematopoietic system phenotype	J:77273
	increased anxiety-related response	J:77273
	increased systemic arterial blood pressure	J:81893, J:86774
	normal nervous system phenotype	J:77273

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23