Rgs2^tm1.1Kjb
Targeted Allele Detail

Summary

• Symbol: Rgs2^tm1.1Kjb
• Name: regulator of G-protein signaling 2; targeted mutation 1.1, Kendall J Blumer
• MGI ID: MGI:5426401
• Gene: Rgs2 Location: Chr1:143875076-143879887 bp, - strand Genetic Position: Chr1, 62.56 cM
• Alliance: Rgs2^tm1.1Kjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184284
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted in intron1 and a floxed PGK-neomycin selection cassette was inserted in intron 4. The selection casette was subsequently removed from properly targeted ES cells by cre excision leaving exons 2-4 flanked by loxP sites. (J:184284)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs2 Mutation: 20 strains or lines available

References

• Original: J:184284 Osei-Owusu P, et al., Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem. 2012 Apr 6;287(15):12541-9
• All: 1 reference(s)