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Targeted Allele Detail
Symbol: Rgs2tm1Pngr
Name: regulator of G-protein signaling 2; targeted mutation 1, Josef M Penninger
MGI ID: MGI:2388144
Synonyms: rgs2-
Gene: Rgs2  Location: Chr1:143875076-143879887 bp, - strand  Genetic Position: Chr1, 62.56 cM
Alliance: Rgs2tm1Pngr page
Germline Transmission:  Earliest citation of germline transmission: J:77273
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 4 and 5 with a PGK-neo cassette in the reverse orientation. Northern blot analysis of brain RNA using a full-length cDNA probe confirmed the null allele in homozygous mutant animals. (J:77273)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs2 Mutation:  21 strains or lines available
Original:  J:77273 Oliveira-Dos-Santos AJ, et al., Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12272-7
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory