Kdm6a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kdm6a
lysine (K)-specific demethylase 6A
MGI:1095419

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	impaired skeletal muscle regeneration	J:232700
Kdm6a^{Gt(RRA094)Byg}/Y X/Uty^{Gt(XS0378)Wtsi} either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	abnormal heart morphology	J:201868
	embryonic lethality during organogenesis, complete penetrance	J:201868
	failure of heart looping	J:201868
	myocardial trabeculae hypoplasia	J:201868
	pericardial edema	J:201868
	small heart	J:201868
	thin interventricular septum	J:201868
	thin ventricular wall	J:201868
Kdm6a^tm1Cdcn/Y Tg(CAG-cre/Esr1)5Amc/0 Trp53^tm1Tyj/Trp53^tm1Tyj involves: 129S2/SvPas C57BL/6J * CBA * FVB/N	anemia	J:263565
	decreased erythrocyte cell number	J:263565
	enlarged spleen	J:263565
	increased chronic myelocytic leukemia incidence	J:263565
	increased granulocyte monocyte progenitor cell number	J:263565
	increased hematopoietic stem cell number	J:263565
	increased monocyte cell number	J:263565
	increased myeloid cell number	J:263565
	increased neutrophil cell number	J:263565
	premature death	J:263565
	thrombocytopenia	J:263565

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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