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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rad50
RAD50 double strand break repair protein
MGI:109292
78 phenotypes from 11 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Rad50tm3Jpt/Rad50tm4.1Jpt
involves: 129/Sv * C57BL/6 		abnormal intestine morphology J:209141
postnatal lethality, complete penetrance J:209141
Rad50tm1Flv/Rad50tm1Flv
involves: 129S6/SvEvTac * C57BL/6 		abnormal T-helper 2 physiology J:94870
decreased interleukin-4 secretion J:94870
decreased interleukin-5 secretion J:94870
decreased interleukin-13 secretion J:94870
Rad50tm1Jpt/Rad50tm1Jpt
involves: 129S7/SvEvBrd 		abnormal developmental patterning J:56083
decreased cell proliferation J:56083
decreased embryo size J:56083
embryonic growth arrest J:56083
embryonic lethality between implantation and somite formation, complete penetrance J:56083
increased cellular sensitivity to gamma-irradiation J:56083
Rad50tm1Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal hematopoietic system physiology J:103922
anemia J:103922
increased lymphoma incidence J:103922
premature death J:103922
Rad50tm1Jpt/Rad50tm3Jpt
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
involves: 129/Sv * C57BL/6 		abnormal intestine morphology J:209141
postnatal lethality, complete penetrance J:209141
Rad50tm1Jpt/Rad50tm3Jpt
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal hepatocyte morphology J:144766
decreased bone marrow cell number J:144766
decreased hepatocyte proliferation J:144766
liver hypoplasia J:144766
Rad50tm1Jpt/Rad50tm3Jpt
Tg(Pcp2-cre)2Mpin/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal gait J:144766
normal nervous system phenotype J:144766
Rad50tm1Jpt/Rad50tm4.1Jpt
involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 		prenatal lethality, complete penetrance J:209141
Rad50tm2.1Flv/Rad50tm2.1Flv
B6.129S6-Rad50tm2.1Flv 		decreased interleukin-4 secretion J:196154
decreased interleukin-5 secretion J:196154
decreased interleukin-13 secretion J:196154
Rad50tm2.1Flv/Rad50tm2.2Flv
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal airway resistance J:165055
abnormal CD4-positive, alpha beta T cell morphology J:165055
abnormal DNA methylation J:165055
abnormal T-helper 1 physiology J:165055
abnormal T-helper 2 physiology J:165055
decreased airway responsiveness J:165055
decreased IgE level J:165055
decreased inflammatory response J:165055
decreased interferon-gamma secretion J:165055
decreased interleukin-4 secretion J:165055
decreased interleukin-5 secretion J:165055
decreased interleukin-13 secretion J:165055
normal immune system phenotype J:165055
Rad50tm2.2Flv/Rad50tm2.2Flv
involves: 129S6/SvEvTac * C3H * C57BL/6 		prenatal lethality, complete penetrance J:165055
Rad50tm2Jpt/Rad50tm2Jpt
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6) 		abnormal bone marrow cell morphology/development J:78820
abnormal immune system cell morphology J:78820
abnormal immune system organ morphology J:78820
abnormal spleen morphology J:78820
abnormal thymus morphology J:78820
absent bone marrow cell J:78820
anemia J:78820
decreased B cell number J:78820
decreased body weight J:78820
decreased immature B cell number J:78820
decreased pre-B cell number J:78820
decreased T cell number J:78820
impaired hematopoiesis J:78820
increased late pro-B cell number J:78820
increased leukemia incidence J:78820
increased macrophage cell number J:78820
increased T cell derived lymphoma incidence J:78820
lethality throughout fetal growth and development, incomplete penetrance J:78820
premature death J:78820
spleen hyperplasia J:78820
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd 		anemia J:129762
premature death J:129762
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow cell morphology/development J:103922
anemia J:103922
decreased double-negative T cell number J:103922
decreased macrophage cell number J:103922
decreased pro-B cell number J:103922
increased lymphoma incidence J:103922
pancytopenia J:103922
premature death J:103922
thrombocytopenia J:103922
Rad50tm3.1Flv/Rad50tm3.1Flv
B6.129S6-Rad50tm3.1Flv 		decreased interleukin-4 secretion J:196154
decreased interleukin-5 secretion J:196154
decreased interleukin-13 secretion J:196154
Rad50tm4.1Flv/Rad50tm4.1Flv
B6.129S6-Rad50tm4.1Flv 		decreased interleukin-5 secretion J:196154
decreased interleukin-13 secretion J:196154
increased interleukin-4 secretion J:196154
increased interleukin-5 secretion J:196154
increased interleukin-13 secretion J:196154
Rad50tm4.1Jpt/Rad50+
involves: 129/Sv * C57BL/6 		abnormal fertility/fecundity J:209141
abnormal gametogenesis J:209141
abnormal hematopoietic stem cell morphology J:209141
abnormal seminiferous tubule morphology J:209141
abnormal sperm number J:209141
abnormal spermatogenesis J:209141
decreased litter size J:209141
female infertility J:209141
hydrocephaly J:209141
impaired hematopoiesis J:209141
increased foot pad pigmentation J:209141
increased hepatoblastoma incidence J:209141
increased liver adenoma incidence J:209141
increased liver tumor incidence J:209141
increased skin pigmentation J:209141
increased tail pigmentation J:209141
male infertility J:209141
ovary atrophy J:209141
reduced female fertility J:209141
small testis J:209141
testicular atrophy J:209141
Rad50tm4Jpt/Rad50+
involves: 129/Sv * C57BL/6 		hydrocephaly J:209141
increased liver adenoma incidence J:209141
increased liver tumor incidence J:209141
Rad50tm5Jpt/Rad50+
involves: 129/Sv * C57BL/6 		prenatal lethality, complete penetrance J:209141
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory