Phex Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Phex
phosphate regulating endopeptidase homolog, X-linked
MGI:107489

125 phenotypes from 12 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Phex^Hpr/Y involves: C3H/HeH * C57BL/6J	abnormal bone structure	J:187142
	abnormal vertebrae morphology	J:187142
	decreased bone mineral density	J:187142
	decreased circulating phosphate level	J:187142
	increased circulating alkaline phosphatase level	J:187142
	increased diameter of femur	J:187142
	short femur	J:187142
Phex^Hpr/Phex⁺ involves: C3H/HeH * C57BL/6J	abnormal bone structure	J:187142
	abnormal long bone morphology	J:187142
	abnormal vertebrae morphology	J:187142
	decreased bone mineral density	J:187142
	decreased circulating phosphate level	J:187142
	decreased length of long bones	J:187142
	increased circulating alkaline phosphatase level	J:187142
	increased diameter of femur	J:187142
	short femur	J:187142
Phex^Hyp-2J/Y C57BL/6-Phex^Hyp-2J/J	abnormal craniofacial bone morphology	J:88352
	abnormal patella morphology	J:88352
	abnormal scala tympani morphology	J:88352
	decreased body weight	J:88352
	decreased bone mineral density	J:88352
	decreased circulating calcium level	J:88352
	decreased circulating potassium level	J:88352
	decreased length of long bones	J:88352
	disorganized long bone epiphyseal plate	J:88352
	normal hearing/vestibular/ear phenotype	J:88352
	increased diameter of long bones	J:88352
	short femur	J:88352
	short fibula	J:88352
	short hindlimb	J:88352
	short tail	J:88352
	short tibia	J:88352
	small cranium	J:88352
Phex^Hyp-2J/Phex⁺ C57BL/6-Phex^Hyp-2J/J	abnormal postnatal growth/weight/body size	J:88352
	short hindlimb	J:88352
	short tail	J:88352
Phex^Hyp-Duk/Y B6.C-Phex^Hyp-Duk/J	abnormal cranium morphology	J:132678
	abnormal otic capsule morphology	J:132678
	normal behavior/neurological phenotype	J:132678
	decreased body size	J:132678
	normal hearing/vestibular/ear phenotype	J:132678
	increased or absent threshold for auditory brainstem response	J:132678
Phex^Hyp-Duk/Y involves: BALB/cAnBomUrd	abnormal cochlea morphology	J:88352
	abnormal craniofacial bone morphology	J:88352
	abnormal gait	J:132678
	abnormal limb bone morphology	J:88352
	abnormal otic capsule morphology	J:132678
	abnormal patella morphology	J:88352
	abnormal scala tympani morphology	J:88352
	abnormal temporal bone morphology	J:88352
	abnormal vestibular saccule morphology	J:132678
	circling	J:88352
	cochlear ganglion degeneration	J:88352, J:132678
	decreased body weight	J:88352
	decreased bone mineral density	J:88352
	decreased circulating calcium level	J:88352
	decreased circulating potassium level	J:88352
	decreased length of long bones	J:88352
	decreased total body fat amount	J:88352
	disorganized long bone epiphyseal plate	J:88352
	distended Reissner membrane	J:132678
	ear inflammation	J:132678
	head bobbing	J:132678
	normal hearing/vestibular/ear phenotype	J:132678
	impaired hearing	J:132678
	increased diameter of long bones	J:88352
	increased or absent threshold for auditory brainstem response	J:88352, J:132678
	increased susceptibility to otitis media	J:132678
	organ of Corti degeneration	J:88352
	postnatal growth retardation	J:88352
	short femur	J:88352
	short fibula	J:88352
	short hindlimb	J:88352
	short maxilla	J:88352
	short tail	J:88352
	short tibia	J:88352
	small cranium	J:88352
	unilateral deafness	J:132678
Phex^Hyp-Duk/Phex⁺ involves: BALB/cAnBomUrd	circling	J:88352
	postnatal growth retardation	J:88352
	short hindlimb	J:88352
	short tail	J:88352
Phex^Hyp/Y B6.Cg-Phex^Hyp/J	abnormal caudal vertebrae morphology	J:87808
	abnormal intestinal absorption	J:137343
	abnormal patella morphology	J:88352
	decreased body weight	J:88352
	decreased bone mineral density	J:88352
	decreased bone mineralization	J:67356
	decreased circulating calcium level	J:88352
	decreased circulating phosphate level	J:87808
	decreased circulating potassium level	J:88352
	decreased length of long bones	J:88352
	disorganized long bone epiphyseal plate	J:88352
	increased diameter of long bones	J:88352
	increased or absent threshold for auditory brainstem response	J:88352
	osteomalacia	J:87808
	short femur	J:88352
	short fibula	J:88352
	short hindlimb	J:88352
	short tail	J:88352
	short tibia	J:88352
	small caudal vertebrae	J:87808
Phex^Hyp/Phex⁺ B6.Cg-Phex^Hyp/J	abnormal caudal vertebrae morphology	J:87808
	abnormal intestinal absorption	J:137343
	abnormal postnatal growth/weight/body size	J:88352
	normal cellular phenotype	J:87808
	decreased circulating phosphate level	J:87808
	osteomalacia	J:87808
	short hindlimb	J:88352
	short tail	J:88352
	small caudal vertebrae	J:87808
Phex^Hyp/Y involves: C3H/HeSnJ * C57BL/6J	abnormal intestinal absorption	J:17152
Phex^Hyp/Y involves: C3H/HeSnJ * C57BL/6J	decreased circulating phosphate level	J:17152
Phex^Hyp/Y involves: C57BL/6	abnormal renal glucose reabsorption	J:8335
	abnormal urine nucleotide level	J:8335
	decreased circulating phosphate level	J:8335
	increased circulating alkaline phosphatase level	J:8335
	increased urine phosphate level	J:8335
Phex^Hyp/? involves: C57BL/6J	abnormal chondrocyte physiology	J:99866
	abnormal fibrocartilage morphology	J:192371
	decreased circulating phosphate level	J:99866
	enthesitis	J:192371
	increased width of hypertrophic chondrocyte zone	J:99866
	rickets	J:99866
Phex^Hyp/Y involves: C57BL/6J	abnormal cranial suture morphology	J:1654
	abnormal cranium morphology	J:1654
	decreased body weight	J:17152
	decreased circulating phosphate level	J:17152
	decreased cranium height	J:1654
	decreased intestinal calcium absorption	J:17152
	domed cranium	J:1654
	short frontal bone	J:1654
	short mandible	J:1654
	short nasal bone	J:1654
	short premaxilla	J:1654
Phex^Hyp/Phex⁺ involves: C57BL/6J	decreased body weight	J:17152
	decreased circulating phosphate level	J:17152
	decreased intestinal calcium absorption	J:17152
Phex^Hyp/Y Not Specified	abnormal bone mineralization	J:110579
	abnormal long bone hypertrophic chondrocyte zone	J:110579
	abnormal osteocyte lacuna morphology	J:131043
	abnormal osteocyte lacunocanalicular system morphology	J:131043
	abnormal renal phosphate reabsorption	J:131043
	abnormal vitamin D level	J:110579
	decreased body length	J:110579
	decreased body weight	J:110579
	decreased bone mineral density	J:110579
	decreased circulating phosphate level	J:110579, J:131043
	decreased length of long bones	J:131043
	osteomalacia	J:131043
	rickets	J:110579
	short femur	J:131043
Phex^Hyp/Phex⁺ Tg(Bglap2-Phex)1Ldq/? involves: C57BL/6J	abnormal bone mineralization	J:74324
	decreased bone mass	J:74324
	decreased circulating phosphate level	J:74324
	osteomalacia	J:74324
	rickets	J:74324
Phex^Hyp/Phex^Hyp B6.Cg-Phex^Hyp/J	abnormal caudal vertebrae morphology	J:87808
	decreased circulating phosphate level	J:87808
	maternal effect	J:87808
	osteomalacia	J:87808
	small caudal vertebrae	J:87808
Phex^Hyp/Phex^Hyp involves: C3H/HeSnJ * C57BL/6J	abnormal intestinal absorption	J:17152
Phex^Hyp/Phex^Hyp involves: C3H/HeSnJ * C57BL/6J	decreased circulating phosphate level	J:17152
Phex^Hyp/Phex^Hyp involves: C57BL/6J	abnormal cranial suture morphology	J:1654
	abnormal cranium morphology	J:1654
	decreased cranium height	J:1654
	domed cranium	J:1654
	short frontal bone	J:1654
	short mandible	J:1654
	short nasal bone	J:1654
	short premaxilla	J:1654
Phex^m1Jrt/Phex⁺ B6.129S1-Phex^M1Jrt	abnormal joint morphology	J:196537
	abnormal pelvic girdle bone morphology	J:196537
	camptomelia	J:196537
	decreased body length	J:196537
	decreased body size	J:196537
	decreased body weight	J:196537
	decreased circulating calcium level	J:196537
	decreased circulating phosphate level	J:196537
	decreased length of long bones	J:196537
	increased circulating alkaline phosphatase level	J:196537
	small vertebrae	J:196537
Phex^m1Jrt/Y B6.129S1-Phex^M1Jrt	abnormal compact bone morphology	J:196537
	abnormal long bone epiphyseal plate morphology	J:196537
	abnormal long bone epiphyseal plate proliferative zone	J:196537
	abnormal osteoid morphology	J:196537
	decreased body weight	J:196537
	decreased bone mineral content	J:196537
	decreased bone mineral density	J:196537
	decreased circulating calcium level	J:196537
	decreased circulating phosphate level	J:196537
	decreased diameter of femur	J:196537
	increased circulating alkaline phosphatase level	J:196537
	increased long bone epiphyseal plate size	J:196537
	osteomalacia	J:196537
	normal skeleton phenotype	J:196537
Phex^Mhdabap012/Phex^Mhdabap012 C3HeB/FeJ-Phex^Mhdabap012	circling	J:183993
	decreased circulating phosphate level	J:183993
	increased circulating alkaline phosphatase level	J:183993
	short hindlimb	J:183993
Phex^Mhdabap024/Y C3HeB/FeJ-Phex^Mhdabap024	abnormal blood homeostasis	J:264682
	abnormal compact bone morphology	J:264682
	normal cardiovascular system phenotype	J:264682
	decreased bone mineral density	J:264682
	decreased circulating C-reactive protein level	J:264682
	decreased circulating phosphate level	J:264682
	decreased systemic arterial systolic blood pressure	J:264682
	decreased urine calcium level	J:264682
	decreased vitamin D level	J:264682
	increased activity of parathyroid	J:264682
	increased circulating parathyroid hormone level	J:264682
	increased urine creatinine level	J:264682
	normal liver/biliary system phenotype	J:264682
	oliguria	J:264682
	normal renal/urinary system phenotype	J:264682
Phex^Mhdabap024/Phex⁺ C3HeB/FeJ-Phex^Mhdabap024	abnormal blood homeostasis	J:264682
	normal cardiovascular system phenotype	J:264682
	decreased circulating phosphate level	J:264682
	decreased urine calcium level	J:264682
	increased activity of parathyroid	J:264682
	increased circulating parathyroid hormone level	J:264682
	increased urine phosphate level	J:264682
	normal renal/urinary system phenotype	J:264682
Phex^Mhdabap024/Phex^Mhdabap024 C3HeB/FeJ-Phex^Mhdabap024	circling	J:183993
	decreased body size	J:183993
	decreased circulating alkaline phosphatase level	J:183993
	decreased circulating phosphate level	J:183993
Phex^Pug/Phex⁺ involves: C57BL/6J	decreased body size	J:136463
	short hindlimb	J:136463
	short tail	J:136463
Phex^Pug/Y involves: C57BL/6J	abnormal bone mineralization	J:136463
	abnormal skeleton morphology	J:136463
	abnormal tail development	J:136463
	decreased body length	J:136463
	decreased body size	J:136463
	decreased bone mineral density	J:136463
	decreased bone mineral density of vertebrae	J:136463
	decreased chondrocyte apoptosis	J:136463
	decreased circulating calcium level	J:136463
	decreased circulating phosphate level	J:136463
	disorganized long bone epiphyseal plate	J:136463
	disproportionate dwarf	J:136463
	increased trabecular bone volume	J:136463
	short hindlimb	J:136463
	short tail	J:136463
Phex^Pug/Phex^Pug involves: C57BL/6J	disproportionate dwarf	J:136463
Phex^Ska1/Phex⁺ C57BL/6-Phex^Ska1	abnormal acetabulum morphology	J:79953
	abnormal caudal vertebrae morphology	J:79953
	abnormal gait	J:79953
	abnormal limb long bone morphology	J:79953
	abnormal obturator foramen morphology	J:79953
	abnormal pelvic girdle bone morphology	J:79953
	abnormal rib morphology	J:79953
	abnormal skeleton morphology	J:79953
	decreased bone mineral density	J:79953
	decreased bone mineral density of femur	J:79953
	decreased circulating phosphate level	J:79953
	decreased compact bone thickness	J:79953
	exostosis	J:79953
	increased circulating alkaline phosphatase level	J:79953
	short femur	J:79953
	short fibula	J:79953
	short hindlimb	J:79953
	short humerus	J:79953
	short radius	J:79953
	short tibia	J:79953
	short ulna	J:79953
	small clavicle	J:79953
Phex^Ska1/Y C57BL/6-Phex^Ska1	abnormal acetabulum morphology	J:79953
	abnormal caudal vertebrae morphology	J:79953
	abnormal gait	J:79953
	abnormal hindlimb morphology	J:79953
	abnormal limb long bone morphology	J:79953
	abnormal obturator foramen morphology	J:79953
	abnormal pelvic girdle bone morphology	J:79953
	abnormal rib morphology	J:79953
	abnormal skeleton morphology	J:79953
	decreased circulating phosphate level	J:79953
	exostosis	J:79953
	increased circulating alkaline phosphatase level	J:79953
	short femur	J:79953
	short fibula	J:79953
	short hindlimb	J:79953
	short humerus	J:79953
	short radius	J:79953
	short tibia	J:79953
	short ulna	J:79953
	small clavicle	J:79953
Phex^Ska1/Phex^Ska1 C57BL/6-Phex^Ska1	abnormal acetabulum morphology	J:79953
	abnormal bone mineralization	J:79953
	abnormal caudal vertebrae morphology	J:79953
	abnormal costochondral joint morphology	J:79953
	abnormal gait	J:79953
	abnormal limb long bone morphology	J:79953
	abnormal long bone epiphyseal plate morphology	J:79953
	abnormal long bone metaphysis morphology	J:79953
	abnormal osteoclast physiology	J:79953
	abnormal pelvic girdle bone morphology	J:79953
	decreased bone mineral density	J:79953
	decreased bone mineral density of femur	J:79953
	decreased bone resorption	J:79953
	decreased circulating calcium level	J:79953
	decreased circulating phosphate level	J:79953
	decreased compact bone thickness	J:79953
	exostosis	J:79953
	increased circulating alkaline phosphatase level	J:79953
	increased width of hypertrophic chondrocyte zone	J:79953
	osteomalacia	J:79953
	rickets	J:79953
	short femur	J:79953
	short hindlimb	J:79953
Phex^tm1.1Mkd/Y Tg(BGLAP-cre)1Clem/0 B6.Cg-Phex^tm1.1Mkd Tg(BGLAP-cre)1Clem	abnormal osteocyte lacuna morphology	J:131043
	abnormal osteocyte lacunocanalicular system morphology	J:131043
	abnormal renal phosphate reabsorption	J:131043
	decreased circulating phosphate level	J:131043
	decreased length of long bones	J:131043
	osteomalacia	J:131043
	short femur	J:131043
Phex^tm1.2Mkd/Y B6.129-Phex^tm1.2Mkd	abnormal osteocyte lacuna morphology	J:131043
	abnormal osteocyte lacunocanalicular system morphology	J:131043
	abnormal renal phosphate reabsorption	J:131043
	decreased circulating phosphate level	J:131043
	decreased length of long bones	J:131043
	osteomalacia	J:131043
	short femur	J:131043
Tg(Bglap2-Phex)1Ldq/? involves: C57BL/6J	no abnormal phenotype detected	J:74324

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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