66 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aptxtm1Pmc/Aptx+ Atmtm2.1Mfgc/Atmtm2.1Mfgc involves: 129 * C57BL/6	decreased survivor rate	J:316365
	increased thymoma incidence	J:316365
Aptxtm1Pmc/Aptxtm1Pmc Atmtm2.1Mfgc/Atmtm2.1Mfgc involves: 129 * C57BL/6	abnormal CD4-positive helper T cell morphology	J:316365
	abnormal gait	J:316365
	abnormal motor coordination/balance	J:316365
	abnormal nervous system electrophysiology	J:316365
	abnormal Purkinje cell dendrite morphology	J:316365
	abnormal Purkinje cell morphology	J:316365
	abnormal synaptic physiology	J:316365
	abnormal T cell differentiation	J:316365
	ataxia	J:316365
	cerebellum atrophy	J:316365
	decreased body weight	J:316365
	decreased survivor rate	J:316365
	decreased T cell number	J:316365
	impaired coordination	J:316365
	impaired neuron physiology	J:316365
	impaired righting response	J:316365
	increased CD8-positive, alpha-beta T cell number	J:316365
	increased excitatory postsynaptic current frequency	J:316365
	increased thymoma incidence	J:316365
	neurodegeneration	J:316365
	slow postnatal weight gain	J:316365
	thin cerebellar molecular layer	J:316365
Atmtm1Awb/Atm+ involves: 129/Sv * 129S6/SvEvTac * C57BL/6	abnormal seminiferous tubule morphology	J:209141
	abnormal testis size	J:209141
	normal hematopoietic system phenotype	J:209141
	normal nervous system phenotype	J:209141
Atmtm1Awb/Atm+ Rad50tm2Jpt/Rad50tm2Jpt involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	anemia	J:103922
	decreased macrophage cell number	J:103922
	increased lymphoma incidence	J:103922
	premature death	J:103922
Atmtm1Awb/Atmtm1Awb Cep63Gt(EUCE0251h11)Hmgu/Cep63Gt(EUCE0251h11)Hmgu involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	thin cerebral cortex	J:224364
Atmtm1Awb/Atmtm1Awb Nbntm1Jpt/Nbntm1Jpt involves: 129S6/SvEvTac * 129S7/SvEvBrd	embryonic lethality, complete penetrance	J:75956
Atmtm1Awb/Atmtm1Awb Nbntm2.1Jpt/Nbntm2.1Jpt involves: 129S6/SvEvTac * 129/Sv	decreased cellular sensitivity to ionizing radiation	J:129762
Atmtm1Awb/Atmtm1Awb Paxxem1Spj/Paxxem1Spj involves: A/J * C57BL/6NTac	abnormal class switch recombination	J:236776
	decreased B cell number	J:236776
	decreased splenocyte number	J:236776
	decreased T cell number	J:236776
	normal mortality/aging	J:236776
Atmtm1Awb/Atmtm1Awb Pim1tm1Mjn/Pim1+ involves: 129 * 129S6/SvEvTac * C57BL/6J	normal cellular phenotype	J:194229
Atmtm1Awb/Atmtm1Awb Ppm1dtm1Lad/Ppm1dtm1Lad Tg(IghMyc)22Bri/0 involves: 129 * C57BL * FVB/N * SJL	increased tumor incidence	J:120284
	premature death	J:120284
Atmtm1Awb/Atmtm1Awb Rad50tm2Jpt/Rad50tm2Jpt involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	abnormal cell cycle checkpoint function	J:103922
	anemia	J:103922
	normal cellular phenotype	J:103922
	chromosome breakage	J:103922
	increased lymphoma incidence	J:103922
	premature death	J:103922
Atmtm1Awb/Atmtm1Awb Rad50tm4.1Jpt/Rad50+ involves: 129/Sv * 129S6/SvEvTac * C57BL/6	increased tumor latency	J:209141
Atmtm1Awb/Atmtm1Awb Rad52tm1Aps/Rad52tm1Aps involves: 129P2/OlaHsd * 129S6/SvEvTac	decreased body weight	J:90941
	decreased CD4-positive, alpha-beta T cell number	J:90941
	decreased CD8-positive, alpha-beta T cell number	J:90941
	decreased lymphoma incidence	J:90941
	increased mortality induced by gamma-irradiation	J:90941
	increased T cell derived lymphoma incidence	J:90941
	premature death	J:90941
Atmtm1Fwa/Atmtm1Fwa H2axtm1Fwa/H2axtm1Fwa involves: 129S4/SvJae * 129S6/SvEvTac	chromosomal instability	J:138190
	embryonic lethality during organogenesis, complete penetrance	J:138190
	increased cell death	J:138190
	spontaneous chromosome breakage	J:138190
Atmtm1Fwa/Atmtm1Fwa Pknox1tm1Fbla/Pknox1+ involves: 129S4/SvJae * C57BL/6	embryonic growth retardation	J:165811
Atmtm1Fwa/Atmtm1Fwa Pknox1tm1Fbla/Pknox1tm1Fbla involves: 129S4/SvJae * C57BL/6	abnormal pluripotent precursor cell morphology	J:165811
	embryonic growth retardation	J:165811
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:165811
Atmtm1Led/Atm+ Kat8tm2Thl/Kat8+ involves: 129S1/Sv * 129S6/SvEvTac	premature death	J:128936
Atmtm1Led/Atmtm1Led Kat8tm2Thl/Kat8+ involves: 129S1/Sv * 129S6/SvEvTac	decreased body weight	J:128936
	premature death	J:128936
Atmtm1Pmc/Atm+ Lig4tm1Icrf/Lig4tm1Icrf either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	increased neuron apoptosis	J:65540
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4+ either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	increased neuron apoptosis	J:65540
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4tm1Icrf either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	decreased body size	J:65540
	decreased neuron apoptosis	J:65540, J:111068
	neonatal lethality, complete penetrance	J:65540, J:111068
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Icrf/Lig4tm1Icrf involves: 129	decreased cellular sensitivity to ionizing radiation	J:144172
	perinatal lethality	J:144172
Atmtm1Pmc/Atmtm1Pmc Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/SvImJ * C57BL/6 * SJL	ataxia	J:144172
	normal nervous system phenotype	J:144172
Atmtm1Pmc/Atmtm1Pmc Trp73tm2Mak/Trp73tm2Mak involves: 129P2/OlaHsd * C57BL/6J	decreased cellular sensitivity to gamma-irradiation	J:157905
	decreased thymocyte apoptosis	J:157905
Atmtm2Pmc/Atmtm2Pmc Atrtm2Bal/Atrtm2Bal Tg(Nes-cre)1Kln/0 involves: 129S2/SvPas * C57BL/6 * SJL	abnormal nervous system morphology	J:181920
	abnormal neuron apoptosis	J:181920
	decreased cellular sensitivity to ionizing radiation	J:181920
Atmtm2Pmc/Atmtm2Pmc Pnkptm1.1Pmc/Pnkptm1.1Pmc Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * C57BL/6 * SJL	abnormal brain interneuron morphology	J:226703
	increased brain apoptosis	J:226703
	intracranial hemorrhage	J:226703
Xrcc2tm1Pmc/Xrcc2tm1Pmc Atmtm1Pmc/Atmtm1Pmc involves: 129S1/Sv	embryonic lethality during organogenesis, complete penetrance	J:111068