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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Zic3
zinc finger protein of the cerebellum 3
MGI:106676
120 phenotypes from 6 alleles in 19 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mesp1tm2(cre)Ysa/Mesp1+
Zic3tm2.1Jwb/Y
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA/JNCrlj 		no abnormal phenotype detected J:192577
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Zic3tm2.1Jwb/Y
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:192577
Zic3Bn/Zic3+
BNT/LeJ 		decreased caudal vertebrae number J:63168
kinked tail J:13124, J:14983, J:63168
short tail J:13124, J:14983, J:63168
situs ambiguus J:62608
Zic3Bn/0
involves: BNT/LeJ * C57BL/6J 		abnormal cerebellar hemisphere morphology J:101328
abnormal cerebellum vermis lobule III morphology J:101328
abnormal cerebellum vermis lobule V morphology J:101328
abnormal horizontal vestibuloocular reflex J:101328
normal behavior/neurological phenotype J:101328
cerebellum vermis hypoplasia J:101328
hypoactivity J:101328
impaired coordination J:101328
Zic3Bn/Zic3Bn
BNT/LeJ 		abnormal interfrontal bone morphology J:5776
abnormal neurocranium morphology J:5776
cranioschisis J:5776, J:63168
decreased caudal vertebrae number J:63168
exencephaly J:5776, J:63168
increased cranium width J:5776
kinked tail J:13124, J:14983, J:62608, J:63168
open neural tube J:5776, J:63168
postnatal growth retardation J:63168
premature death J:13124, J:14983
prenatal lethality, incomplete penetrance J:63168
reduced fertility J:13124, J:14983, J:63168
short tail J:13124, J:14983, J:62608, J:63168
situs ambiguus J:62608
Zic3Ka/Y
B6.C(C3H)-Zic3Ka 		abnormal direction of heart looping J:196367
abnormal egg cylinder morphology J:196367
abnormal embryonic-extraembryonic boundary morphology J:196367
Zic3Ka/Zic3+
involves: BALB/cOlaHsd * C3H/HeH 		kinked tail J:93195
Zic3Ka/Y
involves: BALB/cOlaHsd * C3H/HeH 		abnormal heart looping J:93195
abnormal left-right axis patterning J:93195
Zic3Ka/Zic3Ka
involves: BALB/cOlaHsd * C3H/HeH 		abnormal heart looping J:93195
abnormal left-right axis patterning J:93195
Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA 		abnormal gastrulation J:194989
abnormal heart looping J:194989
abnormal heart morphology J:194989
abnormal neural tube morphology J:194989
Zic3tm1.1Smwa/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		no abnormal phenotype detected J:194989
Zic3tm1.1Smwa/Y
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:194989
Zic3tm1.1Smwa/Y
Tg(Mef2c-cre)#Blk/0
Not Specified 		no abnormal phenotype detected J:194989
Zic3tm1.1Smwa/Y
Tg(Myh7-cre)1Jmk/0
Not Specified 		no abnormal phenotype detected J:194989
Zic3tm1.1Smwa/Y
Tg(Nodal-cre)16Hmd/0
involves: C57BL/6 		no abnormal phenotype detected J:194989
Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0
involves: C3H * C57BL/6 		abnormal heart looping J:194989
abnormal left-right axis patterning J:194989
abnormal primitive node morphology J:194989
Zic3tm1Bca/Y
involves: 129S7/SvEvBrd 		abnormal direction of heart looping J:192577
abnormal endoderm development J:194989
abnormal head morphology J:192577
abnormal heart looping J:192577
abnormal inferior vena cava morphology J:192577
abnormal motile primary cilium morphology J:194989
abnormal neural tube morphology J:192577
abnormal primitive node morphology J:194989
abnormal stomach position or orientation J:192577
cleft palate J:192577
dextrocardia J:192577
double outlet right ventricle J:192577
embryonic growth retardation J:192577
exencephaly J:192577
heterotaxia J:192577
lung situs inversus J:192577
prenatal lethality, complete penetrance J:75951
preweaning lethality, incomplete penetrance J:192577
right aortic arch J:192577
right-sided stomach J:192577
situs inversus J:192577
ventricular septal defect J:192577
Zic3tm1Bca/Y
involves: 129S7/SvEvBrd * C57BL/6 		abnormal axial skeleton morphology J:75951
abnormal basal ganglion morphology J:75951
abnormal cardiovascular system morphology J:75951
abnormal cerebral cortex morphology J:75951
abnormal diencephalon morphology J:75951
abnormal embryo turning J:75951
abnormal forebrain morphology J:75951
abnormal heart development J:75951
abnormal heart looping J:75951
abnormal heart position or orientation J:75951
abnormal hippocampus morphology J:75951
abnormal left-right axis patterning J:75951
abnormal liver morphology J:75951
abnormal midbrain morphology J:75951
abnormal olfactory nerve morphology J:75951
abnormal rib morphology J:75951
abnormal vertebrae morphology J:75951
absent cerebellum J:75951
anencephaly J:75951
atrial septal defect J:75951
d-loop transposition of the great arteries J:75951
delayed neural tube closure J:75951
disorganized thalamus J:75951
embryonic growth retardation J:75951
exencephaly J:75951
interrupted aortic arch J:75951
kinked tail J:75951
left pulmonary isomerism J:75951
lung situs inversus J:75951
open neural tube J:75951
postnatal lethality, incomplete penetrance J:75951
prenatal lethality, incomplete penetrance J:75951
right aortic arch J:75951
right pulmonary isomerism J:75951
right-sided stomach J:75951
spleen hypoplasia J:75951
ventricular septal defect J:75951
vertebral transformation J:75951
Zic3tm1Bca/Zic3+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal axial skeleton morphology J:75951
abnormal basal ganglion morphology J:75951
abnormal cardiovascular system morphology J:75951
abnormal cerebral cortex morphology J:75951
abnormal diencephalon morphology J:75951
abnormal embryo turning J:75951
abnormal forebrain morphology J:75951
abnormal heart development J:75951
abnormal heart looping J:75951
abnormal heart position or orientation J:75951
abnormal hippocampus morphology J:75951
abnormal left-right axis patterning J:75951
abnormal liver morphology J:75951
abnormal midbrain morphology J:75951
abnormal olfactory nerve morphology J:75951
abnormal rib morphology J:75951
abnormal vertebrae morphology J:75951
absent cerebellum J:75951
anencephaly J:75951
atrial septal defect J:75951
d-loop transposition of the great arteries J:75951
delayed neural tube closure J:75951
disorganized thalamus J:75951
embryonic growth retardation J:75951
exencephaly J:75951
interrupted aortic arch J:75951
kinked tail J:75951
left pulmonary isomerism J:75951
lung situs inversus J:75951
open neural tube J:75951
postnatal lethality, incomplete penetrance J:75951
right aortic arch J:75951
right pulmonary isomerism J:75951
right-sided stomach J:75951
spleen hypoplasia J:75951
ventricular septal defect J:75951
vertebral transformation J:75951
Zic3tm1Bca/Y
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal anterior primitive streak morphology J:106144
abnormal anterior visceral endoderm morphology J:106144
abnormal embryo development J:106144
abnormal embryonic epiblast morphology J:106144
abnormal embryonic neuroepithelial layer differentiation J:106144
abnormal embryonic tissue morphology J:106144
abnormal extraembryonic tissue morphology J:106144
abnormal gastrulation J:106144
abnormal heart looping J:106144
abnormal left-right axis patterning J:106144
abnormal left-right axis symmetry of the somites J:106144
abnormal mesoderm development J:106144
abnormal neural plate morphology J:106144
abnormal primitive streak elongation J:106144
abnormal primitive streak morphology J:106144
abnormal rostral-caudal axis patterning J:106144
abnormal somite development J:106144
absent primitive node J:106144
caudal body truncation J:106144
embryonic growth arrest J:106144
embryonic growth retardation J:106144
embryonic lethality, complete penetrance J:106144
rostral-caudal axis duplication J:106144
small allantois J:106144
split notochord J:106144
Zic3tm1Bca/Y
involves: 129S7/SvEvBrd * Swiss 		prenatal lethality, incomplete penetrance J:75951
Zic3tm1Bca/Zic3tm1Bca
involves: 129S7/SvEvBrd 		abnormal direction of heart looping J:192577
abnormal head morphology J:192577
abnormal heart looping J:192577
abnormal heart position or orientation J:192577
abnormal inferior vena cava morphology J:192577
abnormal lung position or orientation J:192577
abnormal neural tube morphology J:192577
abnormal stomach position or orientation J:192577
atrial septal defect J:192577
cleft palate J:192577
dextrocardia J:192577
embryonic growth retardation J:192577
exencephaly J:192577
heterotaxia J:192577
open neural tube J:192577
preweaning lethality, incomplete penetrance J:192577
right-sided stomach J:192577
situs inversus J:192577
Zic3tm1Bca/Zic3tm1Bca
involves: 129S7/SvEvBrd * C57BL/6 		abnormal axial skeleton morphology J:75951
abnormal basal ganglion morphology J:75951
abnormal cardiovascular system morphology J:75951
abnormal cerebral cortex morphology J:75951
abnormal diencephalon morphology J:75951
abnormal embryo turning J:75951
abnormal forebrain morphology J:75951
abnormal heart development J:75951
abnormal heart looping J:75951
abnormal heart position or orientation J:75951
abnormal hippocampus morphology J:75951
abnormal left-right axis patterning J:75951
abnormal liver morphology J:75951
abnormal midbrain morphology J:75951
abnormal olfactory nerve morphology J:75951
abnormal rib morphology J:75951
abnormal vertebrae morphology J:75951
absent cerebellum J:75951
anencephaly J:75951
atrial septal defect J:75951
d-loop transposition of the great arteries J:75951
delayed neural tube closure J:75951
disorganized thalamus J:75951
embryonic growth retardation J:75951
exencephaly J:75951
interrupted aortic arch J:75951
left pulmonary isomerism J:75951
lung situs inversus J:75951
open neural tube J:75951
postnatal lethality, incomplete penetrance J:75951
prenatal lethality, incomplete penetrance J:75951
right aortic arch J:75951
right pulmonary isomerism J:75951
right-sided stomach J:75951
spleen hypoplasia J:75951
ventricular septal defect J:75951
vertebral transformation J:75951
Zic3tm1Bca/Zic3tm1Bca
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal anterior primitive streak morphology J:106144
abnormal anterior visceral endoderm morphology J:106144
abnormal embryo development J:106144
abnormal embryonic epiblast morphology J:106144
abnormal embryonic neuroepithelial layer differentiation J:106144
abnormal embryonic tissue morphology J:106144
abnormal extraembryonic tissue morphology J:106144
abnormal gastrulation J:106144
abnormal heart looping J:106144
abnormal left-right axis patterning J:106144
abnormal left-right axis symmetry of the somites J:106144
abnormal mesoderm development J:106144
abnormal neural plate morphology J:106144
abnormal primitive streak elongation J:106144
abnormal primitive streak morphology J:106144
abnormal rostral-caudal axis patterning J:106144
abnormal somite development J:106144
absent primitive node J:106144
caudal body truncation J:106144
embryonic growth arrest J:106144
embryonic growth retardation J:106144
embryonic lethality, complete penetrance J:106144
rostral-caudal axis duplication J:106144
small allantois J:106144
split notochord J:106144
Zic3tm1Jwb/Y
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal cricoid cartilage morphology J:117748
abnormal ear position J:117748
abnormal hyoid bone morphology J:117748
abnormal jaw morphology J:117748
abnormal left-right axis patterning J:117748
abnormal mandible morphology J:117748
abnormal zygomatic bone morphology J:117748
absent hyoid bone greater horns J:117748
decreased rib number J:117748
developmental cataract J:117748
dextrocardia J:117748
ectopia cordis J:117748
hemifacial hypoplasia J:117748
kinked tail J:117748
kyphosis J:117748
lowered ear position J:117748
malocclusion J:117748
mandibular coronoid process hypoplasia J:117748
maxilla hypoplasia J:117748
postnatal growth retardation J:117748
premature death J:117748
premaxilla hypoplasia J:117748
scoliosis J:117748
Zic3tm1Jwb/Zic3tm1Jwb
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J) 		abnormal cricoid cartilage morphology J:117748
abnormal ear position J:117748
abnormal hyoid bone morphology J:117748
abnormal jaw morphology J:117748
abnormal left-right axis patterning J:117748
abnormal mandible morphology J:117748
abnormal zygomatic bone morphology J:117748
absent hyoid bone greater horns J:117748
decreased rib number J:117748
developmental cataract J:117748
dextrocardia J:117748
hemifacial hypoplasia J:117748
kinked tail J:117748
kyphosis J:117748
lowered ear position J:117748
malocclusion J:117748
mandibular coronoid process hypoplasia J:117748
maxilla hypoplasia J:117748
postnatal growth retardation J:117748
premature death J:117748
premaxilla hypoplasia J:117748
scoliosis J:117748
Zic3tm2.1Jwb/Y
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:192577
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal anus morphology J:192577
abnormal axial skeleton morphology J:192577
abnormal direction of heart looping J:192577
abnormal embryo development J:192577
abnormal eye morphology J:192577
abnormal heart looping J:192577
abnormal heart position or orientation J:192577
abnormal inferior vena cava morphology J:192577
abnormal lung position or orientation J:192577
abnormal neural tube morphology J:192577
abnormal stomach position or orientation J:192577
atrial septal defect J:192577
cleft palate J:192577
dextrocardia J:192577
embryonic growth retardation J:192577
exencephaly J:192577
heterotaxia J:192577
hindlimb paralysis J:192577
kinked tail J:192577
lethality throughout fetal growth and development, incomplete penetrance J:192577
right-sided stomach J:192577
ventricular septal defect J:192577
Zic3tm2.1Jwb/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * CBA/J 		no abnormal phenotype detected J:192577
Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C3H * C57BL/6 		abnormal heart looping J:192577
heterotaxia J:192577
kinked tail J:192577
preweaning lethality, incomplete penetrance J:192577
Zic3tm2.1Jwb/Zic3tm2.1Jwb
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:192577
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory