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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tfap2a
transcription factor AP-2, alpha
MGI:104671
59 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Chd7Gt(XK403)Byg/\Chd7+
\Tfap2atm1(cre)Moon/\Tfap2a+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		normal embryo phenotype J:154590
\Fgf8tm1.4Mrt/\Fgf8+
\Tfap2atm1Will/\Tfap2atm2.1Will
involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss 		abnormal midface morphology J:217408
abnormal nasal pit morphology J:217408
cleft primary palate J:217408
unilateral cleft palate J:217408
\Fgf8tm1Mrc/\Fgf8tm1Moon
\Tfap2atm1(cre)Moon/\Tfap2a+
involves: 129/Sv * C57BL/6 		abnormal blood vessel morphology J:87304
abnormal coronary artery morphology J:87304
abnormal craniofacial morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal subclavian artery morphology J:87304
absent fourth pharyngeal arch artery J:87304
absent sixth pharyngeal arch artery J:87304
enlarged third pharyngeal arch artery J:87304
fourth pharyngeal arch artery hypoplasia J:87304
interrupted aortic arch, type b J:87304
pharyngeal arch hypoplasia J:87304
postnatal lethality, complete penetrance J:87304
prenatal lethality, incomplete penetrance J:87304
retroesophageal right subclavian artery J:87304
right aortic arch J:87304
\Fgf8tm1Mrc/\Fgf8tm2Mrc
\Tfap2atm1(cre)Moon/\Tfap2a+
involves: 129/Sv * C57BL/6 		abnormal blood vessel morphology J:87304
abnormal coronary artery morphology J:87304
abnormal craniofacial morphology J:87304
abnormal fourth pharyngeal arch artery morphology J:87304
abnormal neural crest cell apoptosis J:87304
abnormal pharyngeal arch artery morphology J:87304
abnormal subclavian artery morphology J:87304
absent fourth pharyngeal arch artery J:87304
absent sixth pharyngeal arch artery J:87304
enlarged third pharyngeal arch artery J:87304
fourth pharyngeal arch artery hypoplasia J:87304
interrupted aortic arch, type b J:87304
pharyngeal arch hypoplasia J:87304
postnatal lethality, complete penetrance J:87304
prenatal lethality, incomplete penetrance J:87304
retroesophageal right subclavian artery J:87304
right aortic arch J:87304
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sor+
\Meis2tm1.1Zkoz/\Meis2tm1.1Zkoz
\Tfap2atm1(cre)Moon/\Tfap2a+
involves: 129 * C57BL/6J 		abnormal cardiac neural crest cell morphology J:229604
abnormal cardiac outflow tract development J:229604
abnormal cartilage morphology J:229604
abnormal facial nerve morphology J:229604
abnormal heart valve morphology J:229604
abnormal hyoid bone morphology J:229604
abnormal mandible morphology J:229604
abnormal otic capsule morphology J:229604
abnormal palate morphology J:229604
abnormal parietal bone morphology J:229604
abnormal tongue muscle morphology J:229604
abnormal trigeminal nerve morphology J:229604
abnormal vestibulocochlear nerve morphology J:229604
absent interparietal bone J:229604
decreased cornea thickness J:229604
decreased tongue size J:229604
double outlet right ventricle J:229604
failure of eyelid fusion J:229604
neonatal lethality, complete penetrance J:229604
short mandible J:229604
small trigeminal ganglion J:229604
\Hoxb1tm5Mrc/\Hoxb1tm7Mrc
\Tfap2atm1(cre)Moon/\Tfap2a+
involves: 129S1/Sv * 129X1/SvJ 		normal behavior/neurological phenotype J:91364
decreased motor neuron number J:91364
\Pknox1tm1.1Xzh/\Pknox1tm1.1Xzh
\Tfap2atm1(cre)Moon/\Tfap2a+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		normal vision/eye phenotype J:182769
\Pygo2tm1.1Ssp/\Pygo2tm1.2Ssp
\Tfap2atm1(cre)Moon/?
involves: 129S1/Sv * 129X1/SvJ 		abnormal lens induction J:121416
small lens J:121416
\Tbx1tm1Bld/\Tbx1tm2.1Bem
\Tfap2atm1(cre)Moon/\Tfap2a+
either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL) 		aberrant origin of the right subclavian artery J:154590
abnormal aortic arch morphology J:154590
abnormal cardiac outflow tract development J:154590
athymia J:154590
cleft palate J:154590
persistent truncus arteriosus J:154590
thymus hypoplasia J:154590
ventricular septal defect J:154590
\Tbx1tm2.1Bem/\Tbx1+
\Tfap2atm1(cre)Moon/\Tfap2a+
either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL) 		fourth pharyngeal arch artery hypoplasia J:154590
\Tfap2atm1Hsv/\Tfap2atm2Will
\Tfap2ctm1Will/\Tfap2ctm2Will
\Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * FVB/N 		normal embryo phenotype J:113442
embryonic lethality between implantation and somite formation, incomplete penetrance J:113442
\Tfap2atm2Will/\Tfap2a+
\Tfap2ctm1Will/\Tfap2ctm2Will
\Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * FVB/N 		abnormal embryonic tissue morphology J:113442
abnormal extraembryonic tissue morphology J:113442
decreased embryo size J:113442
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory