GO Annotations Graph

• Symbol: Atf4
• Name: activating transcription factor 4
• ID: MGI:88096

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008140	cAMP response element binding protein binding	IDA	J:198492
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IGI	J:115876
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:210921
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198492
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198927
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:89403
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:137331
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:237331
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:237331
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140296	general transcription initiation factor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043522	leucine zipper domain binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:121664
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:121664
Molecular Function	GO:0005515	protein binding	IPI	J:113939
Molecular Function	GO:0005515	protein binding	IPI	J:45936
Molecular Function	GO:0005515	protein binding	IPI	J:198492
Molecular Function	GO:0005515	protein binding	IPI	J:2973
Molecular Function	GO:0005515	protein binding	IPI	J:100180
Molecular Function	GO:0005515	protein binding	IPI	J:89403
Molecular Function	GO:0005515	protein binding	IPI	J:88780
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:83554
Molecular Function	GO:0005515	protein binding	IPI	J:115876
Molecular Function	GO:0005515	protein binding	IPI	J:193213
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:88780
Molecular Function	GO:0005515	protein binding	IPI	J:237331
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:198492
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:176743
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:210921
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:83554
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:97566
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	ISO	J:164563
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	IDA	J:217287
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	IBA	J:265628
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IDA	J:217287
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	ISO	J:164563
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:1990617	CHOP-ATF4 complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:148804
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:88780
Cellular Component	GO:0005737	cytoplasm	IDA	J:193213
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:1990037	Lewy body core	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0034399	nuclear periphery	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9635380
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9644310
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9644330
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9653747
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9654760
Cellular Component	GO:0005634	nucleus	IDA	J:124910
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:148804
Cellular Component	GO:0005634	nucleus	IDA	J:89403
Cellular Component	GO:0005634	nucleus	NAS	J:217287
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:193213
Cellular Component	GO:0005634	nucleus	IDA	J:88780
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	NAS	J:124910
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:217287
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:237331
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:115876
Biological Process	GO:0030282	bone mineralization	IMP	J:89403
Biological Process	GO:0034198	cellular response to amino acid starvation	IDA	J:99455
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:137331
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:124910
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	ISO	J:121664
Biological Process	GO:1990253	cellular response to leucine starvation	IDA	J:121664
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:137331
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:176743
Biological Process	GO:0007623	circadian rhythm	IEP	J:176743
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:74479
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:198492
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	ISO	J:155856
Biological Process	GO:0006094	gluconeogenesis	IDA	J:76767
Biological Process	GO:0140468	HRI-mediated signaling	ISO	J:164563
Biological Process	GO:0140467	integrated stress response signaling	IMP	J:137331
Biological Process	GO:0140467	integrated stress response signaling	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:167725
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:198492
Biological Process	GO:0070982	L-asparagine metabolic process	ISO	J:164563
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:74479
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:56007
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:62578
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:99455
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249904
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:155856
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:164563
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:85101
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IMP	J:124910
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IDA	J:137331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:176743
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:124910
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:237331
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:237331
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IMP	J:167725
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	IMP	J:237331
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	IMP	J:237331
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:217287
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:62578
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:198927
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:89403
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:137331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:210921
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121664
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97566
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:237331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:83554
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:115876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:237331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:237331
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:217287
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:186974
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:155856
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:164563
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:167725
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:189996
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:76767
Biological Process	GO:0045667	regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045667	regulation of osteoblast differentiation	IMP	J:89403
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:85101
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:217287
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:83554
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:167725
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:99455
Biological Process	GO:0031667	response to nutrient levels	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:97566