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Src Gene Detail
Summary
  • Symbol
    Src
  • Name
    src proto-oncogene, non-receptor tyrosine kinase
  • Synonyms
    pp60c-src
  • Feature Type
    protein coding gene
  • IDs
    MGI:98397
    NCBI Gene: 20779
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157265828-157313758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.35 cM
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1183 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98397
 protein coding gene Chr2:157260364-157313782 (+)
129S1/SvImJ ENSMUSG00200015361
 protein coding gene Chr2:154124524-154177971 (+)
A/J ENSMUSG00195019798
 protein coding gene Chr2:154497698-154551232 (+)
AKR/J ENSMUSG00220012511
 protein coding gene Chr2:153802270-153855286 (+)
BALB/cJ ENSMUSG00180048055
 protein coding gene Chr2:153946249-153999302 (+)
C3H/HeJ ENSMUSG00175047076
 protein coding gene Chr2:154696487-154749521 (+)
C57BL/6NJ ENSMUSG00215027117
 protein coding gene Chr2:154109723-154163142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024576
 protein coding gene Chr2:149384390-149439670 (+)
CAST/EiJ ENSTCUG00005045322
 protein coding gene Chr2:153094906-153147941 (+)
CBA/J ENSMUSG00210015514
 protein coding gene Chr2:154627564-154680602 (+)
DBA/2J ENSMUSG00185048786
 protein coding gene Chr2:154344166-154397147 (+)
FVB/NJ ENSMUSG00205025345
 protein coding gene Chr2:153378607-153431654 (+)
JF1/MsJ ENSUMUG00000006999
 protein coding gene Chr2:154000502-154053513 (+)
LP/J ENSMUSG00230039358
 protein coding gene Chr2:155922127-155975563 (+)
NOD/ShiLtJ ENSMUSG00190036232
 protein coding gene Chr2:154016059-154069090 (+)
NZO/HlLtJ ENSMUSG00225050131
 protein coding gene Chr2:163942350-163996087 (+)
PWK/PhJ ENSLUMG00010045111
 protein coding gene Chr2:153935387-153988415 (+)
SPRET/EiJ ENSMSPG00010028013
 protein coding gene Chr2:156747729-156764273 (+)
WSB/EiJ ENSIUOG00005042611
 protein coding gene Chr2:153707018-153760041 (+)



Homology
more
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
  • Synonyms
    ASV, c-SRC, p60-Src, SRC1, THC6
  • Links
    NCBI Gene ID: 6714
    UniProt: P12931

  • Chr Location
    20q11.23; chr20:37344673-37406050 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Src mouse models; 7 with human SRC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    2 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    314
  • GO References
    73
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    92
  • cDNA Data
    92
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20779 NCBI Gene Model | MGI Sequence Detail 47931 C57BL/6J ±  kb
    transcript NM_001421000 RefSeq | MGI Sequence Detail 4213 C57BL/6  
    polypeptide P05480 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      Genomic 6
      cDNA 95
      Primer pair 4
      Other 3
      Antibodies 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14556, MGI:2139334
    References
    more
    • Summaries
      All 468
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 73
      Phenotypes 106
    • Earliest
      J:318723 Barbehenn EK, et al., The explanation for the blockade of glycolysis in early mouse embryos. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1056-60
    • Latest
      J:390793 Featherstone RE, et al., Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling. JCI Insight. 2026 Jan 23;11(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory