Src Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Src
Rous sarcoma oncogene
MGI:98397

30 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src⁺ involves: 129S7/SvEvBrd	abnormal nursing	J:20346
	reduced female fertility	J:20346
Fyn^tm1Sor/Fyn^tm1Sor Src^tm1Sor/Src^tm1Sor involves: 129S7/SvEvBrd	decreased body size	J:20346
	decreased body weight	J:20346
	postnatal lethality, complete penetrance	J:20346
Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N	normal neoplasm	J:181822
Hck^tm1Hev/Hck^tm1Hev Src^tm1Sor/Src^tm1Sor involves: 129S7/SvEvBrd * C57BL/6J	abnormal bone marrow cavity morphology	J:31647
	abnormal immune system organ morphology	J:31647
	abnormal long bone diaphysis morphology	J:31647
	abnormal skeleton development	J:31647
	abnormal spleen germinal center morphology	J:31647
	abnormal spleen morphology	J:31647
	abnormal splenic cell ratio	J:31647
	abnormal trabecular bone morphology	J:31647
	anemia	J:31647
	decreased bone marrow cell number	J:31647
	decreased leukocyte cell number	J:31647
	increased macrophage cell number	J:31647
	lymph node hypoplasia	J:31647
	perinatal lethality, incomplete penetrance	J:31647
	postnatal growth retardation	J:31647
	premature death	J:31647
	thymus hypoplasia	J:31647
Src^tm1Mul/Src⁺ Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	increased mammary gland tumor incidence	J:181822
Src^tm1Mul/Src^tm1Mul Tg(MMTV-cre)7Mul/0 Tg(MMTV-PyVT)#Mul/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	increased mammary gland tumor incidence	J:181822
Src^tm1Mul/Src^tm1Mul Tg(MMTV-PyVT)#Mul/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	decreased cell proliferation	J:181822
	decreased tumor growth/size	J:181822
	increased apoptosis	J:181822
Src^tm1Sor/Src^tm1Sor Yes1^tm1Sor/Yes1^tm1Sor involves: 129S7/SvEvBrd	abnormal breathing pattern	J:20346
	decreased body size	J:20346
	neonatal lethality, incomplete penetrance	J:20346
	osteopetrosis	J:20346
	premature death	J:20346

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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