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Srctm1Mul
Targeted Allele Detail
Summary
Symbol: Srctm1Mul
Name: Rous sarcoma oncogene; targeted mutation 1, William J Muller
MGI ID: MGI:5314758
Synonyms: c-SrcL
Gene: Src  Location: Chr2:157265828-157313758 bp, + strand  Genetic Position: Chr2, 78.35 cM
Alliance: Srctm1Mul page
Analysis of tumorigenesis

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181822
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo, IRES, and GFP cassette with a 3' loxP site downstream of exon 6. Flp-mediated recombination removed the neo, IRES and GFP cassette. (J:181822)
(A) Generation of the conditional Srctm1Mul allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Src Mutation:  144 strains or lines available
References
Original:  J:181822 Marcotte R, et al., Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2808-13
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory