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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srctm1Mul
targeted mutation 1, William J Muller
MGI:5314758
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N MGI:5314779
cn2
 		Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314776
cn3
 		Srctm1Mul/Src+
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314777
cn4
 		Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314778
cn5
 		Srctm1Mul/Srctm1Mul
Tg(MMTV-PyVT)#Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314780


Genotype
MGI:5314779
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Srctm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:181822 )
N
• mice exhibit the same incidence of lung metastases and average metastatic burden as in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:5314776
cn2
Allelic
Composition		 Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Normal mammary gland branching and ductal outgrowth in Srctm1Mul/Srctm1Mul Tg(MMTV-cre)7Mul/0 mice

reproductive system
reproductive system phenotype ( J:181822 )
N
• mice exhibit normal mammary gland branching and ductal outgrowth




Genotype
MGI:5314777
cn3
Allelic
Composition		 Srctm1Mul/Src+
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Analysis of tumorigenesis

neoplasm
increased mammary gland tumor incidence ( J:181822 )
• with later onset than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:181822 )
• with later onset than in Tg(MMTV-PyVT)#Mul mice

integument
increased mammary gland tumor incidence ( J:181822 )
• with later onset than in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:5314778
cn4
Allelic
Composition		 Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Analysis of tumorigenesis

neoplasm
increased mammary gland tumor incidence ( J:181822 )
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

integument
increased mammary gland tumor incidence ( J:181822 )
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:181822 )
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:5314780
cn5
Allelic
Composition		 Srctm1Mul/Srctm1Mul
Tg(MMTV-PyVT)#Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (144 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased apoptosis ( J:181822 )
• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen
decreased cell proliferation ( J:181822 )
• of tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen

neoplasm
decreased tumor growth/size ( J:181822 )
• tumor cells transfected with a retrovirus expressing a tamoxifen-dependent cre and treated with tamoxifen exhibit impaired proliferation, increased apoptosis and restored cell-cell adhesion compared to in Tg(MMTV-PyVT)#Mul mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory