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Serpina3k Gene Detail
Summary
  • Symbol
    Serpina3k
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3K
  • Synonyms
    1300001I07Rik, alpha-1 antiproteinase, contrapsin, D12Rp54, MMCM2, MMSpi2, RP54, Spi2, Spi-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98377
    NCBI Gene: 20714
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104304745-104311998 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 53.99 cM, cytoband F1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98377
protein coding gene Chr12:104304745-104312403 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020074
protein coding gene Chr12:106109681-106117337 (+)
A/J MGP_AJ_G0020028
protein coding gene Chr12:102100750-102108408 (+)
AKR/J MGP_AKRJ_G0020005
protein coding gene Chr12:105011319-105018975 (+)
BALB/cJ MGP_BALBcJ_G0020014
protein coding gene Chr12:102481456-102489112 (+)
C3H/HeJ MGP_C3HHeJ_G0019816
protein coding gene Chr12:105459091-105496720 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020460
protein coding gene Chr12:109439002-109447456 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018073
protein coding gene Chr12:98817002-98820256 (+)
CAST/EiJ MGP_CASTEiJ_G0019359
protein coding gene Chr12:100312785-100320445 (+)
CBA/J MGP_CBAJ_G0019784
protein coding gene Chr12:113587962-113597062 (+)
DBA/2J MGP_DBA2J_G0019901
protein coding gene Chr12:101608994-101616650 (+)
FVB/NJ MGP_FVBNJ_G0019886
protein coding gene Chr12:100395109-100402639 (+)
LP/J MGP_LPJ_G0019976
protein coding gene Chr12:105959395-105967051 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019924
protein coding gene Chr12:117066571-117075416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020489
protein coding gene Chr12:104473474-104481687 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018922
protein coding gene Chr12:98702689-98710040 (+)
WSB/EiJ MGP_WSBEiJ_G0019417
protein coding gene Chr12:105404335-105496080 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612384-94624055 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human SERPINA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20714 NCBI Gene Model | MGI Sequence Detail 7254 C57BL/6J ±  kb
transcript NM_011458 RefSeq | MGI Sequence Detail 1652 ZRU/MplStud  
polypeptide P07759 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 517
    Genomic 1
    cDNA 515
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14022, MGD-MRK-14521, MGD-MRK-14526, MGD-MRK-3357, MGI:1915688
References
more
  • Summaries
    All 57
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:5549 Wilcox FH, Genetic variation in plasma prealbumin of the house mouse. J Hered. 1975 Jan-Feb;66(1):19-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory