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St3gal1 Gene Detail
Summary
  • Symbol
    St3gal1
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Synonyms
    CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, Siat4, Siat4a, ST3GalI
  • Feature Type
    protein coding gene
  • IDs
    MGI:98304
    NCBI Gene: 20442
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66974724-67048575 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 29.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4026 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98304
 protein coding gene Chr15:66974724-67048679 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021911
 protein coding gene Chr15:66624858-66659663 (-)
A/J MGP_AJ_G0021870
 protein coding gene Chr15:64112034-64138387 (-)
AKR/J MGP_AKRJ_G0021852
 protein coding gene Chr15:65875636-65888430 (-)
BALB/cJ MGP_BALBcJ_G0021877
 protein coding gene Chr15:64291360-64368886 (-)
C3H/HeJ MGP_C3HHeJ_G0021650
 protein coding gene Chr15:66002789-66074515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022316
 protein coding gene Chr15:69208236-69254817 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019853
 protein coding gene Chr15:60890765-60943685 (-)
CAST/EiJ MGP_CASTEiJ_G0021169
 protein coding gene Chr15:66670065-66705933 (-)
CBA/J MGP_CBAJ_G0021616
 protein coding gene Chr15:71495075-71569910 (-)
DBA/2J MGP_DBA2J_G0021741
 protein coding gene Chr15:63888242-63963548 (-)
FVB/NJ MGP_FVBNJ_G0021723
 protein coding gene Chr15:62927991-63002492 (-)
LP/J MGP_LPJ_G0021813
 protein coding gene Chr15:66530392-66600625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021746
 protein coding gene Chr15:76599748-76621736 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022338
 protein coding gene Chr15:66262839-66288781 (-)
PWK/PhJ MGP_PWKPhJ_G0020910
 protein coding gene Chr15:63991775-64014375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020751
 protein coding gene Chr15:66124309-66197593 (-)
WSB/EiJ MGP_WSBEiJ_G0021221
 protein coding gene Chr15:66231953-66255525 (-)



Homology
more
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Synonyms
    Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O
  • Links
    NCBI Gene ID: 6482
    UniProt: Q11201

  • Chr Location
    8q24.22; chr8:133454848-133571926 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    36 phenotype references
Homozygous mutation of this gene results in altered terminal glycosylation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    121
  • cDNA Data
    19
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20442 NCBI Gene Model | MGI Sequence Detail 73852 C57BL/6J ±  kb
transcript NM_001412635 RefSeq | MGI Sequence Detail 5744 C57BL/6  
polypeptide P54751 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14411, MGI:2146025
References
more
  • Summaries
    All 69
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:337723 Hong Y, et al., ST3GAL1 and betaII-spectrin pathways control CAR T cell migration to target tumors. Nat Immunol. 2023 Jun;24(6):1007-1019
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory