Prkca MGI Mouse Gene Detail - MGI:97595

Symbol

Prkca
Name

protein kinase C, alpha
Synonyms

Pkca

Feature Type

protein coding gene
IDs

MGI:97595
NCBI Gene: 18750
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr11:107824213-108234754 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.80 cM
Mapping Data

37 experiments

SNPs within 2kb

2685 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97595	protein coding gene	Chr11:107824213-108237360 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019325	protein coding gene	Chr11:111371037-111810071 (-)
A/J	MGP_AJ_G0019293	protein coding gene	Chr11:106589537-106998980 (-)
AKR/J	MGP_AKRJ_G0019262	protein coding gene	Chr11:109780094-110199485 (-)
BALB/cJ	MGP_BALBcJ_G0019267	protein coding gene	Chr11:107015121-107429715 (-)
C3H/HeJ	MGP_C3HHeJ_G0019076	protein coding gene	Chr11:110088780-110515861 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019717	protein coding gene	Chr11:114792752-115216661 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017341	protein coding gene	Chr11:103853385-104264497 (-)
CAST/EiJ	MGP_CASTEiJ_G0018629	protein coding gene	Chr11:111195888-111625093 (-)
CBA/J	MGP_CBAJ_G0019045	protein coding gene	Chr11:119540387-120000489 (-)
DBA/2J	MGP_DBA2J_G0019157	protein coding gene	Chr11:106070209-106477226 (-)
FVB/NJ	MGP_FVBNJ_G0019148	protein coding gene	Chr11:105577187-105984327 (-)
LP/J	MGP_LPJ_G0019227	protein coding gene	Chr11:111811054-112241563 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019178	protein coding gene	Chr11:118745379-119180835 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019754	protein coding gene	Chr11:110336438-110765390 (-)
PWK/PhJ	MGP_PWKPhJ_G0018394	protein coding gene	Chr11:107217822-107635355 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018185	protein coding gene	Chr11:110091118-110511473 (-)
WSB/EiJ	MGP_WSBEiJ_G0018680	protein coding gene	Chr11:110276224-110698202 (-)

Human Ortholog

PRKCA, protein kinase C alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKCA, protein kinase C alpha
Synonyms

AAG6, PKCA, PKCalpha, PKC-alpha, PKCI+/-, PRKACA
Links

HGNC:9393

NCBI Gene ID: 5578

neXtProt AC: NX_P17252

UniProt: P17252
Chr Location

17q24.2; chr17:66302640-66810744 (+) GRCh38.p7

Alliance of Genome Resources

Prkca stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKCA
Protein SuperFamily

PKC_alpha
Gene Tree

Prkca

Diseases

6 with human PRKCA associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193
				high grade glioma IDs high grade glioma DOID:3070 DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:PS137800 ORDO:182067 UMLS_CUI:C0017638 UMLS_CUI:C0555198
				large cell carcinoma IDs large cell carcinoma DOID:4552 MESH:D018287 NCI:C3780 UMLS_CUI:C0206704
				ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139
				third ventricle chordoid glioma IDs third ventricle chordoid glioma DOID:3773 NCI:C5592 UMLS_CUI:C1322252

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

13 phenotypes from 4 alleles in 5 genetic backgrounds
7 phenotypes from multigenic genotypes
81 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

4
Gene trapped

5
Targeted

3
Transgenic

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show no overt macroscopic abnormalities, however examination of one line revealed increased cardiac muscle contractility and protection against heart failure.

less

All GO Annotations

127
GO References

39

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1013
Tissues

191
cDNA Data

72
Literature Summary

138

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkca

ZFIN prkcaa

less

Prkca interacts with 478 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

45
RefSeq

4
UniProt

3
CCDS

CCDS25573.1

Ensembl

ENSMUSG00000050965 (Evidence)
NCBI Gene

18750

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050965	Ensembl Gene Model \| MGI Sequence Detail	410542	C57BL/6J	± kb
transcript	ENSMUST00000059595	Ensembl \| MGI Sequence Detail	8409	Not Applicable
polypeptide	ENSMUSP00000062392	Ensembl \| MGI Sequence Detail	672	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000003058 protein kinase C alpha type

(term hierarchy)
PDB

6UWA
EC

2.7.11.13
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR034663 Classical Protein Kinase C alpha, catalytic domain

IPR020454 Diacylglycerol/phorbol-ester binding

IPR017441 Protein kinase, ATP binding site

IPR014375 Protein kinase C, alpha/beta/gamma types

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 85

cDNA 74

Primer pair 9

Other 2

Microarray probesets 5

less

MGD-MRK-13327, MGI:2144325

Summaries

All 402

Developmental Gene Expression 138

Gene Ontology 39

Phenotypes 81
Earliest

J:9748 Rose-John S, et al., Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene. 1988 Dec 30;74(2):465-71
Latest

J:330604 Akturk A, et al., RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells. Sci Adv. 2022 Oct 21;8(42):eabq2826

TSS for Prkca:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111511	Chr11:108234945-108235006 (-)	-222 bp
Tssr111510	Chr11:108234916-108234930 (-)	-169 bp
Tssr111509	Chr11:108234770-108234780 (-)	-21 bp
Tssr111508	Chr11:108234743-108234767 (-)	-1 bp
Tssr111507	Chr11:108234705-108234723 (-)	40 bp
Tssr111506	Chr11:108234681-108234692 (-)	67 bp
Tssr111505	Chr11:108234375-108234394 (-)	369 bp
Tssr111504	Chr11:108212410-108212414 (-)	22,342 bp
Tssr111503	Chr11:108186626-108186629 (-)	48,126 bp
Tssr111502	Chr11:108180994-108180998 (-)	53,758 bp
Tssr111501	Chr11:108164610-108164615 (-)	70,141 bp
Tssr111500	Chr11:108164511-108164553 (-)	70,222 bp
Tssr111499	Chr11:108163132-108163136 (-)	71,620 bp
Tssr111498	Chr11:108161341-108161413 (-)	73,377 bp
Tssr111497	Chr11:108153667-108153678 (-)	81,081 bp
Tssr111496	Chr11:108153510-108153529 (-)	81,234 bp
Tssr111495	Chr11:108152070-108152078 (-)	82,680 bp
Tssr111494	Chr11:108139873-108139876 (-)	94,879 bp
Tssr111493	Chr11:108131854-108131874 (-)	102,890 bp
Tssr111492	Chr11:108117832-108117837 (-)	116,919 bp
Tssr111491	Chr11:107935504-107935509 (-)	299,247 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22