Mip MGI Mouse Gene Detail - MGI:96990 - major intrinsic protein of lens fiber

Symbol

Mip
Name

major intrinsic protein of lens fiber
Synonyms

Aqp0, aquaporin 0, Cts, lens opacity, Lop, MIP26, shrivelled, Svl

Feature Type

protein coding gene
IDs

MGI:96990
NCBI Gene: 17339
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:128061707-128067681 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.49 cM, cytoband D1
Mapping Data

11 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96990	protein coding gene	Chr10:128061679-128067681 (+)
129S1/SvImJ	ENSMUSG00200011889	protein coding gene	Chr10:124415497-124421719 (+)
A/J	ENSMUSG00195015489	protein coding gene	Chr10:124878744-124884964 (+)
AKR/J	ENSMUSG00220005072	protein coding gene	Chr10:124484322-124490541 (+)
BALB/cJ	ENSMUSG00180009984	protein coding gene	Chr10:124869711-124875931 (+)
C3H/HeJ	ENSMUSG00175005928	protein coding gene	Chr10:124869322-124875330 (+)
C57BL/6NJ	ENSMUSG00215006638	protein coding gene	Chr10:124480110-124486084 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015924	protein coding gene	Chr10:120586898-120592839 (+)
CAST/EiJ	ENSTCUG00005035173	protein coding gene	Chr10:123867600-123873692 (+)
CBA/J	ENSMUSG00210008849	protein coding gene	Chr10:124693548-124699556 (+)
DBA/2J	ENSMUSG00185023998	protein coding gene	Chr10:124847444-124853418 (+)
FVB/NJ	ENSMUSG00205018568	protein coding gene	Chr10:124089342-124095317 (+)
JF1/MsJ	ENSUMUG00000018939	protein coding gene	Chr10:126157214-126163443 (+)
LP/J	ENSMUSG00230032264	protein coding gene	Chr10:126769401-126775621 (+)
NOD/ShiLtJ	ENSMUSG00190014037	protein coding gene	Chr10:124911100-124917074 (+)
NZO/HlLtJ	ENSMUSG00225036932	protein coding gene	Chr10:130972033-130978045 (+)
PWK/PhJ	ENSLUMG00010008875	protein coding gene	Chr10:124608624-124614888 (+)
SPRET/EiJ	ENSMSPG00010029354	protein coding gene	Chr10:126573763-126578930 (+)
WSB/EiJ	ENSIUOG00005007905	protein coding gene	Chr10:124485455-124491426 (+)

Human Ortholog

MIP, major intrinsic protein of lens fiber

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIP, major intrinsic protein of lens fiber
Synonyms

AQP0, CTRCT15, LIM1, MIP26, MP26
Links

HGNC:7103

NCBI Gene ID: 4284

UniProt: P30301
Chr Location

12q13.3; chr12:56449502-56469166 (-) GRCh38

MGI Vertebrate Homology

Mip stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MIP
Gene Tree

Mip

Diseases

1 with Mip mouse models; 2 with human MIP associations

Human Disease

Mouse Models

cataract 15 multiple types

IDs

View 7 models

cataract

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

5 with disease annotations

References

4 with disease annotations

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Phenotype Summary

12 phenotypes from 6 alleles in 16 genetic backgrounds
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

5
Gene trapped

24
Radiation induced

1
Spontaneous

7
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes have microphthalmia and lens opacity. Other defects may include degeneration of lens fiber cells, vacuolization of lens fibers and reduced gamma:alpha crystallin ratio. Heterozygotes have less severe forms of lens cataract and microphthalmia.

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All GO Annotations

52
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

109
cDNA Data

7
Literature Summary

61

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mip

ZFIN mipa, mipb

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS24265.1

Ensembl

ENSMUSG00000025389 (Evidence)
NCBI Gene

17339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025389	Ensembl Gene Model \| MGI Sequence Detail	5975	C57BL/6J	± kb
transcript	ENSMUST00000026455	Ensembl \| MGI Sequence Detail	2144	Not Applicable
polypeptide	ENSMUSP00000026455	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010911 lens fiber major intrinsic protein

(term hierarchy)
InterPro Domains

IPR023271 Aquaporin-like

IPR034294 Aquaporin transporter

IPR000425 Major intrinsic protein

IPR022357 Major intrinsic protein, conserved site

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All nucleic 21

Genomic 2

cDNA 11

Primer pair 6

Other 2

Antibodies 13

Microarray probesets 4

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MGD-MRK-10701, MGD-MRK-11842, MGD-MRK-12240, MGD-MRK-14658, MGD-MRK-1767, MGD-MRK-2244, MGI:88560, MGI:96076

Summaries

All 155

Developmental Gene Expression 61

Diseases 4

Gene Ontology 15

Phenotypes 54
Earliest

J:285 PAGET OE, [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse.]. Z Indukt Abstamm Vererbungsl. 1953;85(2):238-44
Latest

J:383294 Smolikova J, et al., Meis1 and Meis2 are jointly required for advanced stages of mouse lens morphogenesis. Dev Biol. 2026 Apr 16;

TSS for Mip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96357	Chr10:128061699-128061714 (+)	0 bp
Tssr96358	Chr10:128061812-128061830 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29