Mip^Cat-Fr
Spontaneous Allele Detail

Summary

• Symbol: Mip^Cat-Fr
• Name: major intrinsic protein of lens fiber; dominant cataract Fraser
• MGI ID: MGI:1857104
• Synonyms: Cat⁶⁰, shrivelled, Svl
• Gene: Mip Location: Chr10:128061707-128067681 bp, + strand Genetic Position: Chr10, 76.49 cM, cytoband D1
• Alliance: Mip^Cat-Fr page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: A transposon-induced error in splicing introduces a long terminal repeat sequence replacing the normal carboxy terminus in mutant mice. (J:5045, J:31574)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mip Mutation: 31 strains or lines available

Notes

In chimeric embryos formed between a strain of mice homozygous for Mip^Cat-Fr and the DBA/2 strain, homozygous for the wild-type Mip allele, the lens is histologically, cellularly, and biochemically normal (J:35863). A study of the lens crystallins shows a decrease in the proportion of a-crystallins and an increase in the proportion of a-crystallins (J:6987). At birth, a-crystallin mRNAs are present in nearly normal amounts and functional capacity but are selectively lost by 40 days of age. The effect is more severe in homozygotes than in heterozygotes. The a-crystallin cellular DNA does not differ from normal (J:7668).

References

• Original: J:206638 Fraser FC, et al., 'Shrivelled', a hereditary degeneration of the lens in the house mouse. Genet Res. 1962;3(3):383-387
• All: 16 reference(s)