Gapdh MGI Mouse Gene Detail - MGI:95640 - glyceraldehyde-3-phosphate dehydrogenase

Symbol

Gapdh
Name

glyceraldehyde-3-phosphate dehydrogenase
Synonyms

Gapd

Feature Type

protein coding gene
IDs

MGI:95640
NCBI Gene: 14433
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:125138815-125143430 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.32 cM, cytoband C
Mapping Data

15 experiments

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95640	protein coding gene	Chr6:125138678-125143430 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031288	protein coding gene	Chr6:128493116-128498571 (-)
A/J	MGP_AJ_G0031258	protein coding gene	Chr6:123646354-123651423 (-)
AKR/J	MGP_AKRJ_G0031186	protein coding gene	Chr6:127022456-127026300 (-)
BALB/cJ	MGP_BALBcJ_G0031266	protein coding gene	Chr6:123243458-123248820 (-)
C3H/HeJ	MGP_C3HHeJ_G0030989	protein coding gene	Chr6:127094521-127099833 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031722	protein coding gene	Chr6:131871284-131878724 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028871	protein coding gene	Chr6:120854027-120856276 (-)
CAST/EiJ	MGP_CASTEiJ_G0030370	protein coding gene	Chr6:127297255-127300971 (-)
CBA/J	MGP_CBAJ_G0030950	protein coding gene	Chr6:136933331-136938260 (-)
DBA/2J	MGP_DBA2J_G0031106	protein coding gene	Chr6:122577359-122582080 (-)
FVB/NJ	MGP_FVBNJ_G0031056	protein coding gene	Chr6:121493301-121495617 (-)
LP/J	MGP_LPJ_G0031186	protein coding gene	Chr6:128658162-128662628 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031094	protein coding gene	Chr6:140965165-140968959 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031757	protein coding gene	Chr6:126923934-126928690 (-)
PWK/PhJ	MGP_PWKPhJ_G0030085	protein coding gene	Chr6:120820491-120824655 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029914	protein coding gene	Chr6:124999107-125005018 (-)
WSB/EiJ	MGP_WSBEiJ_G0030455	protein coding gene	Chr6:127294415-127298214 (-)

Human Ortholog

GAPDH, glyceraldehyde-3-phosphate dehydrogenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAPDH, glyceraldehyde-3-phosphate dehydrogenase
Synonyms

G3PD, GAPD, HEL-S-162eP
Links

HGNC:4141

NCBI Gene ID: 2597

neXtProt AC: NX_P04406

UniProt: P04406
Chr Location

12p13.31; chr12:6534405-6538375 (+) GRCh38.p7

Alliance of Genome Resources

Gapdh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GAPDH
Protein SuperFamily

GAP_DH
Gene Tree

Gapdh

Diseases

1 with human GAPDH associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 EFO:0000249 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 10 alleles in 11 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically and radiation induced

1
Chemically induced (ENU)

3
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

12
Radiation induced

2
Spontaneous

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutant heterozygotes show reduced enzyme levels. The currently known mutant allels are homozygous lethal.

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All GO Annotations

72
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

932
Tissues

142
cDNA Data

29
Literature Summary

51

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gapdh

ZFIN gapdh

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Gapdh interacts with 31 markers (Mir30b, Mir128-1, Mir128-2, ...) View All

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All Sequences

207
RefSeq

16
UniProt

8
CCDS

CCDS51913.1, CCDS80613.1

Ensembl

ENSMUSG00000057666 (Evidence)
NCBI Gene

14433

			Length	Strain/Species	Flank
genomic	14433	NCBI Gene Model \| MGI Sequence Detail	4616	C57BL/6J	± kb
transcript	NM_001411845	RefSeq \| MGI Sequence Detail	1633	C57BL/6
polypeptide	P16858	UniProt \| EBI \| MGI Sequence Detail	333	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007840 glyceraldehyde-3-phosphate dehydrogenase

(term hierarchy)
PDB

6LGJ, 6LGK, 6LGM
EC

1.2.1.12, 2.6.99.-
InterPro Domains

IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site

IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain

IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain

IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I

IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 42

cDNA 32

Primer pair 8

Other 2

Microarray probesets 29

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MGD-MRK-9967, MGI:3579984

Summaries

All 185

Developmental Gene Expression 51

Gene Ontology 29

Phenotypes 14
Earliest

J:2409 Crew FAE, et al., The character of "hairless" in the mouse. J Genet. 1931;25:17-24
Latest

J:330824 Babochkina TI, et al., Mother-Fetus Immune Cross-Talk Coordinates "Extrinsic"/"Intrinsic" Embryo Gene Expression Noise and Growth Stability. Int J Mol Sci. 2022 Oct 18;23(20)

TSS for Gapdh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63250	Chr6:125143426-125143462 (-)	-14 bp
Tssr63249	Chr6:125142670-125142729 (-)	730 bp
Tssr63248	Chr6:125142557-125142575 (-)	864 bp
Tssr63247	Chr6:125142312-125142315 (-)	1,116 bp
Tssr63246	Chr6:125142280-125142297 (-)	1,141 bp
Tssr63245	Chr6:125141052-125141069 (-)	2,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 03/14/2023 MGI 6.22