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Cacnb2 Gene Detail
Summary
  • Symbol
    Cacnb2
  • Name
    calcium channel, voltage-dependent, beta 2 subunit
  • Synonyms
    Cavbeta2, Cchb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894644
    NCBI Gene: 12296
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:14607899-14992719 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 10.70 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1245 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894644
 protein coding gene Chr2:14607899-14993622 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025364
 protein coding gene Chr2:12122619-12533321 (+)
A/J MGP_AJ_G0025341
 protein coding gene Chr2:11685256-12068587 (+)
AKR/J MGP_AKRJ_G0025310
 protein coding gene Chr2:12032241-12427572 (+)
BALB/cJ MGP_BALBcJ_G0025337
 protein coding gene Chr2:11677772-12075525 (+)
C3H/HeJ MGP_C3HHeJ_G0025097
 protein coding gene Chr2:11983990-12383652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025779
 protein coding gene Chr2:12429093-12827803 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023194
 protein coding gene Chr2:11198549-11584507 (+)
CAST/EiJ MGP_CASTEiJ_G0024560
 protein coding gene Chr2:11934759-12359075 (+)
CBA/J MGP_CBAJ_G0025076
 protein coding gene Chr2:13033280-13447914 (+)
DBA/2J MGP_DBA2J_G0025208
 protein coding gene Chr2:11584664-11967373 (+)
FVB/NJ MGP_FVBNJ_G0025170
 protein coding gene Chr2:11455771-11837417 (+)
LP/J MGP_LPJ_G0025294
 protein coding gene Chr2:12037947-12439560 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025202
 protein coding gene Chr2:12836320-13264476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025837
 protein coding gene Chr2:11931746-12338923 (+)
PWK/PhJ MGP_PWKPhJ_G0024311
 protein coding gene Chr2:11423463-11815042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024111
 protein coding gene Chr2:11997831-12435782 (+)
WSB/EiJ MGP_WSBEiJ_G0024630
 protein coding gene Chr2:12077016-12481775 (+)



Homology
more
  • Human Ortholog
    CACNB2, calcium voltage-gated channel auxiliary subunit beta 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNB2, calcium voltage-gated channel auxiliary subunit beta 2
  • Synonyms
    CAB2, CACNLB2, CAVB2, MYSB
  • Links
    NCBI Gene ID: 783
    neXtProt AC: NX_Q08289
    UniProt: Q08289

  • Chr Location
    10p12.33-p12.31; chr10:18140424-18543557 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CACNB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality at E10.5 with growth retardation, abnormal yolk vasculature and abnormal cardiac development and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    962
  • Tissues
    105
  • cDNA Data
    19
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057914 Ensembl Gene Model | MGI Sequence Detail 384821 C57BL/6J ±  kb
    transcript ENSMUST00000114723 Ensembl | MGI Sequence Detail 3945 Not Applicable  
    polypeptide ENSMUSP00000110371 Ensembl | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000004947 voltage-dependent L-type calcium channel subunit beta-2
      (term hierarchy)
    • InterPro Domains
      IPR035605 CACNB2, SH3 domain
      IPR008145 Guanylate kinase/L-type calcium channel beta subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
      IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
      IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
      IPR046937 Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 25
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24068, MGI:103200, MGI:2139283, MGI:3583767
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:25718 Massa E, et al., Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr;47(4):707-16
    • Latest
      J:294971 Fecher-Trost C, et al., Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory