About   Help   FAQ
Crygb Gene Detail
Summary
  • Symbol
    Crygb
  • Name
    crystallin, gamma B
  • Synonyms
    Cryg-3, DGcry-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88522
    NCBI Gene: 12965
  • Member of
    Cryg cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65119381-65121449 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.82 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88522
 protein coding gene Chr1:65119378-65121449 (-)
129S1/SvImJ ENSMUSG00200004598
 protein coding gene Chr1:62612626-62614695 (-)
A/J ENSMUSG00195030469
 protein coding gene Chr1:62140562-62142631 (-)
AKR/J ENSMUSG00220037590
 protein coding gene Chr1:62259577-62261646 (-)
BALB/cJ ENSMUSG00180028942
 protein coding gene Chr1:62448149-62450218 (-)
C3H/HeJ ENSMUSG00175000667
 protein coding gene Chr1:62528816-62530885 (-)
C57BL/6NJ ENSMUSG00215014437
 protein coding gene Chr1:62473901-62475970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014216
 protein coding gene Chr1:59030119-59032114 (-)
CAST/EiJ ENSTCUG00005020912
 protein coding gene Chr1:62268362-62270426 (-)
CBA/J ENSMUSG00210003092
 protein coding gene Chr1:62205940-62208009 (-)
DBA/2J ENSMUSG00185004934
 protein coding gene Chr1:63322889-63324958 (-)
FVB/NJ ENSMUSG00205013669
 protein coding gene Chr1:62161305-62163374 (-)
JF1/MsJ ENSUMUG00000001673
 protein coding gene Chr1:62278426-62280506 (-)
LP/J ENSMUSG00230002091
 protein coding gene Chr1:63321786-63323855 (-)
NOD/ShiLtJ ENSMUSG00190013121
 protein coding gene Chr1:62391815-62393884 (-)
NZO/HlLtJ ENSMUSG00225000681
 protein coding gene Chr1:66546394-66548463 (-)
PWK/PhJ ENSLUMG00010007170
 protein coding gene Chr1:61814603-61816683 (-)
SPRET/EiJ ENSMSPG00010018573
 protein coding gene Chr1:63776241-63778307 (-)
WSB/EiJ ENSIUOG00005027359
 protein coding gene Chr1:62006022-62008091 (-)



Homology
more
  • Human Ortholog
    CRYGB, crystallin gamma B
  • Vertebrate Orthologs
    15
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYGB, crystallin gamma B
  • Synonyms
    CRYG2, CTRCT39
  • Links
    NCBI Gene ID: 1419
    UniProt: P07316

  • Chr Location
    2q33.3; chr2:208142573-208146158 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crygb mouse models; 1 with human CRYGB associations

Human Disease Mouse Models
      
IDs
 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes and heterozygotes for a spontaneous mutation exhibit cataracts characterized by nuclear and polar opacity with vacuoles and a reduction in lens weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    39
  • cDNA Data
    66
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12965 NCBI Gene Model | MGI Sequence Detail 2069 C57BL/6J ±  kb
    transcript NM_144761 RefSeq | MGI Sequence Detail 633 ZRU/MplStud  
    polypeptide P04344 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 1
      cDNA 66
      Primer pair 4
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2172, MGD-MRK-2177, MGD-MRK-8838
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:370201 Wei YS, et al., Anp32b Deficiency Suppresses Ocular Development by Repression of Pax6. Ophthalmic Res. 2024;67(1):644-653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory